Literature DB >> 12496897

A novel monoclonal antibody 107-1A4 with high prostate specificity: generation, characterization of antigen expression, and targeting of human prostate cancer xenografts.

L G Brown1, S K Wegner, H Wang, K R Buhler, E W Arfman, P H Lange, R L Vessella.   

Abstract

Monoclonal antibodies with high specificity for prostate tissue are of interest for prostate cancer research and treatment. Reactivity and specificity of a new murine monoclonal antibody, 107-1A4, was assessed by immunohistochemistry, ELISA and indirect immunofluorescence (IDIF). 107-1A4 stained all normal and malignant prostate tissue specimens while reactivity to non-prostate tissue was limited to the tubules of the normal kidney and renal cell carcinoma. Twenty two human cell lines were included in the reactivity survey; only the immunogen prostate cancer line LNCaP reacted with 107-1A4. Seminal plasma proteins PSA, PAP, PSMA, and PSP-94 were determined not to be the 107-1A4 antigen.

Entities:  

Year:  1998        PMID： 12496897     DOI： 10.1038/sj.pcan.4500233

Source DB:  PubMed          Journal:  Prostate Cancer Prostatic Dis        ISSN： 1365-7852            Impact factor:   5.554


  6 in total

1.  Characterization of prostate cell types by CD cell surface molecules.

Authors:  Alvin Y Liu; Lawrence D True
Journal:  Am J Pathol       Date:  2002-01       Impact factor: 4.307

2.  Reagents for astatination of biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab' as a means of decreasing kidney retention.

Authors:  D Scott Wilbur; Ming-Kuan Chyan; Donald K Hamlin; Holly Nguyen; Robert L Vessella
Journal:  Bioconjug Chem       Date:  2011-05-05       Impact factor: 4.774

3.  Preclinical evaluation of a monoclonal antibody (3C6) specific for prostate-specific membrane antigen.

Authors:  C A S Regino; K J Wong; D E Milenic; E H Holmes; K Garmestani; P L Choyke; M W Brechbiel
Journal:  Curr Radiopharm       Date:  2009-01

4.  Evaluation of radioiodinated protein conjugates and their potential metabolites containing lysine-urea-glutamate (LuG), PEG and closo-decaborate(2-) as models for targeting astatine-211 to metastatic prostate cancer.

Authors:  Yawen Li; Ming-Kuan Chyan; Donald K Hamlin; Holly Nguyen; Robert Vessella; D Scott Wilbur
Journal:  Nucl Med Biol       Date:  2020-05-03       Impact factor: 2.408

5.  The dog prostate cancer (DPC-1) model: a reliable tool for molecular imaging of prostate tumors and metastases.

Authors:  Simone Chevalier; Serge Moffett; Eric Turcotte; Murillo Luz; Lyne Chauvette; Vilma Derbekyan; Eleonora Scarlata; Fatima Zouanat; Armen G Aprikian; Maurice Anidjar
Journal:  EJNMMI Res       Date:  2015-12-30       Impact factor: 3.138

6.  Shotgun Glycomics Identifies Tumor-Associated Glycan Ligands Bound by an Ovarian Carcinoma-Specific Monoclonal Antibody.

Authors:  B Liau; B Tan; G Teo; P Zhang; A Choo; P M Rudd
Journal:  Sci Rep       Date:  2017-11-03       Impact factor: 4.379
  6 in total

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