Literature DB >> 12496758

Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.

Bonnie L Seidel-Rogol1, Vicki McCulloch, Gerald S Shadel.   

Abstract

Human mitochondrial transcription factor B1 (h-mtTFB1) has an unprecedented relationship to RNA methyltransferases. Here, we show that this protein methylates a conserved stem-loop in bacterial 16S rRNA and that the homologous sequence in the human mitochondrial 12S molecule is similarly modified. Thus, h-mtTFB1 appears to be dual-function protein, acting both as a transcription factor and an rRNA-modification enzyme.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12496758     DOI： 10.1038/ng1064

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  82 in total

1.  Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro.

Authors:  Dmitry Litonin; Marina Sologub; Yonghong Shi; Maria Savkina; Michael Anikin; Maria Falkenberg; Claes M Gustafsson; Dmitry Temiakov
Journal:  J Biol Chem       Date:  2010-04-21       Impact factor: 5.157

2.  Core human mitochondrial transcription apparatus is a regulated two-component system in vitro.

Authors:  Timothy E Shutt; Maria F Lodeiro; Justin Cotney; Craig E Cameron; Gerald S Shadel
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-18       Impact factor: 11.205

3.  Crystallographic analysis of RsmA, a ribosomal RNA small subunit methyltransferase A from Staphylococcus aureus.

Authors:  Yang Liu; Yuwei Zhu; Maikun Teng; Xu Li
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-07-29       Impact factor: 1.056

4.  Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription.

Authors:  Yulia V Surovtseva; Timothy E Shutt; Justin Cotney; Huseyin Cimen; Sophia Y Chen; Emine C Koc; Gerald S Shadel
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-14       Impact factor: 11.205

5.  Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription.

Authors:  Vishantie Dostal; Mair E A Churchill
Journal:  Biochim Biophys Acta Gene Regul Mech       Date:  2019-02-23       Impact factor: 4.490

6.  Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution.

Authors:  Heather C O'Farrell; Nagesh Pulicherla; Pooja M Desai; Jason P Rife
Journal:  RNA       Date:  2006-03-15       Impact factor: 4.942

7.  Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness.

Authors:  Justin Cotney; Sharen E McKay; Gerald S Shadel
Journal:  Hum Mol Genet       Date:  2009-05-05       Impact factor: 6.150

8.  The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit.

Authors:  Dasmanthie De Silva; Flavia Fontanesi; Antoni Barrientos
Journal:  Cell Metab       Date:  2013-11-05       Impact factor: 27.287

Review 9.  The relationship between pluripotency and mitochondrial DNA proliferation during early embryo development and embryonic stem cell differentiation.

Authors:  J M Facucho-Oliveira; J C St John
Journal:  Stem Cell Rev Rep       Date:  2009-04-03       Impact factor: 5.739

10.  Expression and maintenance of mitochondrial DNA: new insights into human disease pathology.

Authors:  Gerald S Shadel
Journal:  Am J Pathol       Date:  2008-05-05       Impact factor: 4.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.