| Literature DB >> 12496217 |
J A Jeddeloh1, D L Fritz, D M Waag, J M Hartings, G P Andrews.
Abstract
A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease.Entities:
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Year: 2003 PMID: 12496217 PMCID: PMC143420 DOI: 10.1128/IAI.71.1.584-587.2003
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441