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Literature DB >> 12495847

Kinesin motors and disease.

Eckhard Mandelkow¹, Eva-Maria Mandelkow.

Abstract

Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

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Year: 2002 PMID： 12495847 DOI： 10.1016/s0962-8924(02)02400-5

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

34 in total

1. Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila.

Authors: Caroline Mauvezin; Amanda L Neisch; Carlos I Ayala; Jung Kim; Abigail Beltrame; Christopher R Braden; Melissa K Gardner; Thomas S Hays; Thomas P Neufeld
Journal: J Cell Sci Date: 2016-01-13 Impact factor: 5.285

2. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.

Authors: Changjun Zhu; Jian Zhao; Marina Bibikova; Joel D Leverson; Ella Bossy-Wetzel; Jian-Bing Fan; Robert T Abraham; Wei Jiang
Journal: Mol Biol Cell Date: 2005-04-20 Impact factor: 4.138

Review 3. Interaction of kinesin motors, microtubules, and MAPs.

Authors: A Marx; J Müller; E-M Mandelkow; A Hoenger; E Mandelkow
Journal: J Muscle Res Cell Motil Date: 2005-12-17 Impact factor: 2.698

4. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly.

Authors: Cheng Jiang; Yadong Chen; Xiaojian Wang; Qidong You
Journal: J Mol Model Date: 2007-06-23 Impact factor: 1.810

5. Molecular interaction of α-synuclein with tubulin influences on the polymerization of microtubule in vitro and structure of microtubule in cells.

Authors: R M Zhou; Y X Huang; X L Li; C Chen; Q Shi; G R Wang; C Tian; Z Y Wang; Y Y Jing; C Gao; X P Dong
Journal: Mol Biol Rep Date: 2009-10-14 Impact factor: 2.316

6. Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

Authors: Garry L Coles; Kate G Ackerman
Journal: Proc Natl Acad Sci U S A Date: 2013-05-06 Impact factor: 11.205

Kinesin motors and disease.

1. Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila.

2. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.

Review 3. Interaction of kinesin motors, microtubules, and MAPs.

4. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly.

5. Molecular interaction of α-synuclein with tubulin influences on the polymerization of microtubule in vitro and structure of microtubule in cells.

6. Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

7. Methodology for the Simulation of Molecular Motors at Different Scales.

8. Compartmental protein expression of Tau, GSK-3beta and TrkA in cholinergic neurons of aged rats.

9. Native kinesin-1 does not bind preferentially to GTP-tubulin-rich microtubules in vitro.

Review 10. Kinesin and Dynein Mechanics: Measurement Methods and Research Applications.