Literature DB >> 12495846

PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.

Matthew J Wishart1, Jack E Dixon.   

Abstract

The phosphatase and tensin homolog deleted on chromosome ten (PTEN) and myotubularin (MTM1) represent subfamilies of protein tyrosine phosphatases whose principal physiological substrates are D3-phosphorylated inositol phospholipids. As lipid phosphatases, PTEN- and MTM1-related (MTMR) proteins dephosphorylate the products of phosphoinositide 3-kinases and antagonize downstream effectors that utilize 3-phosphoinositides as ligands for protein targeting domains or allosteric activation. Here, we describe the cellular mechanisms of PTEN and MTMR function and their role in the etiology of cancer and other human diseases.

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Year:  2002        PMID： 12495846     DOI： 10.1016/s0962-8924(02)02412-1

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  54 in total

1.  Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation.

Authors:  Alexias Safi; Marie Vandromme; Sabine Caussanel; Laure Valdacci; Dominique Baas; Marc Vidal; Gilbert Brun; Laurent Schaeffer; Evelyne Goillot
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

2.  Membrane-binding and activation mechanism of PTEN.

Authors:  Sudipto Das; Jack E Dixon; Wonhwa Cho
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-13       Impact factor: 11.205

Review 3.  Protein phosphatases in pancreatic islets.

Authors:  Henrik Ortsäter; Nina Grankvist; Richard E Honkanen; Åke Sjöholm
Journal:  J Endocrinol       Date:  2014-03-28       Impact factor: 4.286

4.  Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions.

Authors:  C A Byrum; K D Walton; A J Robertson; S Carbonneau; R T Thomason; J A Coffman; D R McClay
Journal:  Dev Biol       Date:  2006-08-25       Impact factor: 3.582

5.  A new approach to the molecular analysis of docking, priming, and regulated membrane fusion.

Authors:  Tatiana P Rogasevskaia; Jens R Coorssen
Journal:  J Chem Biol       Date:  2011-02-08

6.  Phosphorylation keeps PTEN phosphatase closed for business.

Authors:  Alonzo H Ross; Arne Gericke
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-27       Impact factor: 11.205

7.  Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate.

Authors:  Yong Xu; Stephanie A Lee; Tatiana G Kutateladze; Diego Sbrissa; Assia Shisheva; Glenn D Prestwich
Journal:  J Am Chem Soc       Date:  2006-01-25       Impact factor: 15.419

8.  The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.

Authors:  Alexander Ungewickell; Christopher Hugge; Marina Kisseleva; Shao-Chun Chang; Jun Zou; Yucheng Feng; Edouard E Galyov; Monita Wilson; Philip W Majerus
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-19       Impact factor: 11.205

Review 9.  Class I PI3K in oncogenic cellular transformation.

Authors:  L Zhao; P K Vogt
Journal:  Oncogene       Date:  2008-09-18       Impact factor: 9.867

10.  Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.

Authors:  Harshal H Nandurkar; Meredith Layton; Jocelyn Laporte; Carly Selan; Lisa Corcoran; Kevin K Caldwell; Yasuhiro Mochizuki; Philip W Majerus; Christina A Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-07       Impact factor: 11.205
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