Literature DB >> 12495708

Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon.

F Borrelli1, A A Izzo, G Di Carlo, P Maffia, A Russo, F M Maiello, F Capasso, N Mascolo.   

Abstract

We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.

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Year:  2002        PMID： 12495708     DOI： 10.1016/s0367-326x(02)00189-2

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  20 in total

1.  Effect of caffeic acid phenethyl ester on proliferation and apoptosis of colorectal cancer cells in vitro.

Authors:  Dong Wang; De-Bing Xiang; Yu-Jun He; Zeng-Peng Li; Xiao-Hua Wu; Jiang-Hong Mou; Hua-Liang Xiao; Qing-Hong Zhang
Journal:  World J Gastroenterol       Date:  2005-07-14       Impact factor: 5.742

2.  Role of caffeic acid phenethyl ester on mitomycin C induced clastogenesis: analysis of chromosome aberrations, micronucleus, mitotic index and adenosine deaminase activity in vivo.

Authors:  Ghassan Mohammad Sulaiman
Journal:  J Appl Genet       Date:  2012-03-02       Impact factor: 3.240

3.  Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer.

Authors:  Jing Wu; Coral Omene; Jerzy Karkoszka; Maarten Bosland; Jonathan Eckard; Catherine B Klein; Krystyna Frenkel
Journal:  Cancer Lett       Date:  2011-05-13       Impact factor: 8.679

4.  Inhibitory effect of caffeic acid phenethyl ester on the growth of SW480 colorectal tumor cells involves beta-catenin associated signaling pathway down-regulation.

Authors:  Yu-Jun He; Bao-Hua Liu; De-Bing Xiang; Zuo-Yi Qiao; Tao Fu; Yu-Hong He
Journal:  World J Gastroenterol       Date:  2006-08-21       Impact factor: 5.742

5.  Caffeic acid phenethyl ester triggers apoptosis through induction of loss of mitochondrial membrane potential in CCRF-CEM cells.

Authors:  Cığır Biray Avcı; Cumhur Gündüz; Yusuf Baran; Fahri Sahin; Sunde Yılmaz; Zeynep Ozlem Dogan; Güray Saydam
Journal:  J Cancer Res Clin Oncol       Date:  2010-03-10       Impact factor: 4.553

6.  Propolis and its Active Component, Caffeic Acid Phenethyl Ester (CAPE), Modulate Breast Cancer Therapeutic Targets via an Epigenetically Mediated Mechanism of Action.

Authors:  Coral Omene; Matko Kalac; Jing Wu; Enrica Marchi; Krystyna Frenkel; Owen A O'Connor
Journal:  J Cancer Sci Ther       Date:  2013-10-21

7.  Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis.

Authors:  Paolo Onori; Sharon DeMorrow; Eugenio Gaudio; Antonio Franchitto; Romina Mancinelli; Julie Venter; Shelley Kopriva; Yoshiyuki Ueno; Domenico Alvaro; Jennifer Savage; Gianfranco Alpini; Heather Francis
Journal:  Int J Cancer       Date:  2009-08-01       Impact factor: 7.396

8.  Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B.

Authors:  Ki Won Lee; Nam Joo Kang; Jong Hun Kim; Kyoung Mi Lee; Dong Eun Lee; Haeng Jeon Hur; Hyong Joo Lee
Journal:  Genes Nutr       Date:  2008-02       Impact factor: 5.523

9.  Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.

Authors:  Yu-Jun He; Wan-Ling Li; Bao-Hua Liu; Hui Dong; Zhi-Rong Mou; Yu-Zhang Wu
Journal:  World J Gastroenterol       Date:  2014-09-07       Impact factor: 5.742

10.  Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.

Authors:  S Sale; R G Tunstall; K C Ruparelia; P C Butler; G A Potter; W P Steward; A J Gescher
Journal:  Invest New Drugs       Date:  2006-11       Impact factor: 3.850
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