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Literature DB >> 12495431

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.

Abstract

Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.

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Year: 2003 PMID： 12495431 PMCID： PMC1223206 DOI： 10.1042/BJ20021626

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

128 in total

1. Diffusion-limited translocation mechanism of protein kinase C isotypes.

Authors: M Schaefer; N Albrecht; T Hofmann; T Gudermann; G Schultz
Journal: FASEB J Date: 2001-07 Impact factor: 5.191

2. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1.

Authors: T Gao; A Toker; A C Newton
Journal: J Biol Chem Date: 2001-03-16 Impact factor: 5.157

3. Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone.

Authors: B A Ballif; A Shimamura; E Pae; J Blenis
Journal: J Biol Chem Date: 2001-01-18 Impact factor: 5.157

4. Caenorhabditis elegans PIAK, a phospholipid-independent kinase that activates the AKT/PKB survival kinase.

Authors: Y Li; D Dowbenko; L A Lasky
Journal: J Biol Chem Date: 2001-03-23 Impact factor: 5.157

5. Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival.

Authors: P Flynn; M Wongdagger; M Zavar; N M Dean; D Stokoe
Journal: Curr Biol Date: 2000-11-16 Impact factor: 10.834

6. Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites.

Authors: M L Standaert; G Bandyopadhyay; Y Kanoh; M P Sajan; R V Farese
Journal: Biochemistry Date: 2001-01-09 Impact factor: 3.162

7. Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms.

Authors: A Balendran; G R Hare; A Kieloch; M R Williams; D R Alessi
Journal: FEBS Lett Date: 2000-11-10 Impact factor: 4.124

8. Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.

Authors: K England; J Watson; G Beale; M Warner; J Cross; M Rumsby
Journal: J Biol Chem Date: 2000-12-19 Impact factor: 5.157

9. Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

Authors: K S Cho; J H Lee; S Kim; D Kim; H Koh; J Lee; C Kim; J Kim; J Chung
Journal: Proc Natl Acad Sci U S A Date: 2001-05-08 Impact factor: 11.205

10. Rat protein kinase c zeta gene contains alternative promoters for generation of dual transcripts with 5'-end heterogeneity.

Authors: B S Marshall; G Price; C T Powell
Journal: DNA Cell Biol Date: 2000-12 Impact factor: 3.311

267 in total

1. PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.

Authors: Qiuting Feng; Ruomin Di; Fang Tao; Zai Chang; Shuangshuang Lu; Wenjing Fan; Congjia Shan; Xinli Li; Zhongzhou Yang
Journal: Mol Cell Biol Date: 2010-05-10 Impact factor: 4.272

Review 2. Tuning the signalling output of protein kinase C.

Authors: Corina E Antal; Alexandra C Newton
Journal: Biochem Soc Trans Date: 2014-12 Impact factor: 5.407

3. Ca²+-dependent phosphorylation of RyR2 can uncouple channel gating from direct cytosolic Ca²+ regulation.

Authors: Simon Carter; Samantha J Pitt; John Colyer; Rebecca Sitsapesan
Journal: J Membr Biol Date: 2011-01-28 Impact factor: 1.843

Review 4. Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning.

Authors: Michael Zaugg; Marcus C Schaub
Journal: J Muscle Res Cell Motil Date: 2003 Impact factor: 2.698

Review 5. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.

Authors: Philippe P Roux; John Blenis
Journal: Microbiol Mol Biol Rev Date: 2004-06 Impact factor: 11.056

6. Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines.

Authors: Ludmila Sviridonov; Masha Dobkin-Bekman; Boris Shterntal; Fiorenza Przedecki; Linor Formishell; Shani Kravchook; Liat Rahamim-Ben Navi; Tali Hana Bar-Lev; Marcelo G Kazanietz; Zhong Yao; Rony Seger; Zvi Naor
Journal: Mol Cell Endocrinol Date: 2013-02-01 Impact factor: 4.102

7. Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.

Authors: Michael P Scheid; Michael Parsons; James R Woodgett
Journal: Mol Cell Biol Date: 2005-03 Impact factor: 4.272

8. A probable crosstalk between Ca⁺², reactive oxygen species accumulation and scavenging mechanisms and modulation of protein kinase C activity during seed development in sunflower.

Authors: Anita Thakur; Satish C Bhatla
Journal: Plant Signal Behav Date: 2014-02-12

Review 9. Atypical protein kinase C in cell motility.

Authors: Helan Xiao; Mingyao Liu
Journal: Cell Mol Life Sci Date: 2012-10-25 Impact factor: 9.261

10. Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167.

Authors: Ruslan Rafikov; Sanjiv Kumar; Saurabh Aggarwal; Yali Hou; Archana Kangath; Daniel Pardo; Jeffrey R Fineman; Stephen M Black
Journal: Free Radic Biol Med Date: 2013-11-06 Impact factor: 7.376