| Literature DB >> 12494344 |
Jeong Suk Ko1, Mun-Chual Rho, Mi Yeon Chung, Hye Young Song, Jong Seong Kang, Koanhoi Kim, Hyun Sun Lee, Young Kook Kim.
Abstract
From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM ( 1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4).Entities:
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Year: 2002 PMID： 12494344 DOI： 10.1055/s-2002-36358
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352