| Literature DB >> 12494335 |
Hong-Jie Zhang1, Pamela A Tamez, Zeynep Aydogmus, Ghee Teng Tan, Yoko Saikawa, Kimiko Hashimoto, Masaya Nakata, Nguyen Van Hung, Le Thi Xuan, Nguyen Manh Cuong, D Doel Soejarto, John M Pezzuto, Harry H S Fong.
Abstract
Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3alpha-hydroxyisohop-22(29)-en-24-oic acid, 3beta-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, alpha-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC 50 values below 1 ng/ml.Entities:
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Year: 2002 PMID： 12494335 DOI： 10.1055/s-2002-36350
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352