| Literature DB >> 12494329 |
Hongyan Wang1, Kwok-Min Hui, Yingjie Chen, Suixu Xu, J Tze-Fei Wong, Hong Xue.
Abstract
Twenty-six flavonoids were isolated from Scutellaria baicalensis. Their affinities for the benzodiazepine (BDZ) binding site of GABA A receptor have been studied using [ 3H]flunitrazepam binding to rat cortical membranes in vitro. The structure-activity relationships suggested that 2'-OH flavones exhibited the most potent binding affinity, which could lead to the design and discovery of new BDZ receptor ligands.Entities:
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Year: 2002 PMID： 12494329 DOI： 10.1055/s-2002-36357
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352