Literature DB >> 12493639

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions.

Christoph Borner1.   

Abstract

Members of the Bcl-2 family are crucial integrators of survival and death signals in higher eukaryotes. Although recent studies have provided novel and quite unexpected insights into the mechanisms by which these proteins might issue life permits or death sentences in cells, we are still on the way to fully understand their modes of action. This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation.

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Year:  2003        PMID： 12493639     DOI： 10.1016/s0161-5890(02)00252-3

Source DB:  PubMed          Journal:  Mol Immunol        ISSN： 0161-5890            Impact factor:   4.407


  150 in total

Review 1.  p53's believe it or not: lessons on transcription-independent death.

Authors:  Jerry E Chipuk; Douglas R Green
Journal:  J Clin Immunol       Date:  2003-09       Impact factor: 8.317

Review 2.  The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling.

Authors:  B McLaughlin
Journal:  Apoptosis       Date:  2004-03       Impact factor: 4.677

3.  Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.

Authors:  Wenbin Hu; Fang Wang; Jingsheng Tang; Xinyu Liu; Zhu Yuan; Chunlai Nie; Yuquan Wei
Journal:  J Biol Chem       Date:  2011-11-03       Impact factor: 5.157

4.  Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?

Authors:  Sandra Vogel; Nina Raulf; Stephanie Bregenhorn; Martin L Biniossek; Ulrich Maurer; Peter Czabotar; Christoph Borner
Journal:  J Biol Chem       Date:  2012-01-25       Impact factor: 5.157

Review 5.  Non-caspase proteases: triggers or amplifiers of apoptosis?

Authors:  Karen Schrader; Jisen Huai; Lars Jöckel; Carolin Oberle; Christoph Borner
Journal:  Cell Mol Life Sci       Date:  2010-02-19       Impact factor: 9.261

6.  The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression.

Authors:  Ramla Shahid; Anthony Bugaut; Shankar Balasubramanian
Journal:  Biochemistry       Date:  2010-09-28       Impact factor: 3.162

7.  Sphingosine kinase-1 protects differentiated N2a cells against beta-amyloid25-35-induced neurotoxicity via the mitochondrial pathway.

Authors:  Yang Yang; Min Wang; Bingjie Lv; Rong Ma; Jing Hu; Yaoyan Dun; Shenggang Sun; Gang Li
Journal:  Neurochem Res       Date:  2014-03-30       Impact factor: 3.996

8.  3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells.

Authors:  Kecheng Lei; Shaoying Tan; Wenpei Du; Yichun Xu; Shengchao Lin; Yuanhong Zheng; Fangyuan Zou; Yufang Xu; Jianwen Liu
Journal:  Tumour Biol       Date:  2015-02-27

9.  Celastrol from 'Thunder God Vine' protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of Parkinson's disease.

Authors:  Bong-Suk Choi; Hyool Kim; Hyo Jeong Lee; Kumar Sapkota; Se Eun Park; Seung Kim; Sung-Jun Kim
Journal:  Neurochem Res       Date:  2013-11-09       Impact factor: 3.996

10.  The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.

Authors:  Dangsheng Li; Sharmistha Das; Tatsuya Yamada; Herbert H Samuels
Journal:  Mol Cell Biol       Date:  2004-05       Impact factor: 4.272
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