Literature DB >> 12493539

Imaging [18F]FAU [1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) uracil] in dogs.

Haihao Sun1, Jerry M Collins, Thomas J Mangner, Otto Muzik, Anthony F Shields.   

Abstract

We have studied the biodistribution of [(18)F]FAU [(1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil], which previous work has shown is incorporated into DNA and functions as an inhibitor of DNA synthesis. It is being tested as a potential antineoplastic agent and imaging agent for PET. We have produced [(18)F]FAU and injected the tracer into 3 normal dogs and imaged them for up to 4 hours and removed tissues along with blood and urine samples for HPLC and activity analysis. The results showed that [(18)F]FAU evenly distributed to most of organs. In sharp contrast to our prior experience with thymidine and its analogs, marrow had less retention of [(18)F]FAU than the non-proliferating tissues. Copyright 2002 Elsevier Science Inc.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12493539     DOI： 10.1016/s0969-8051(02)00376-1

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  5 in total

1.  Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer.

Authors:  Haihao Sun; Andrew Sloan; Thomas J Mangner; Ulka Vaishampayan; Otto Muzik; Jerry M Collins; Kirk Douglas; Anthony F Shields
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-01       Impact factor: 9.236

2.  Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase.

Authors:  Jing Li; Seongho Kim; Anthony F Shields; Kirk A Douglas; Christopher I McHugh; Jawana M Lawhorn-Crews; Jianmei Wu; Thomas J Mangner; Patricia M LoRusso
Journal:  J Clin Pharmacol       Date:  2016-11       Impact factor: 3.126

Review 3.  The role of DNA synthesis imaging in cancer in the era of targeted therapeutics.

Authors:  Sridhar Nimmagadda; Anthony F Shields
Journal:  Cancer Metastasis Rev       Date:  2008-12       Impact factor: 9.264

4.  Herpes simplex virus thymidine kinase imaging in mice with (1-(2'-deoxy-2'-[18F]fluoro-1-β-D-arabinofuranosyl)-5-iodouracil) and metabolite (1-(2'-deoxy-2'-[18F]fluoro-1-β-D-arabinofuranosyl)-5-uracil).

Authors:  Sridhar Nimmagadda; Thomas J Mangner; Jawana M Lawhorn-Crews; Uwe Haberkorn; Anthony F Shields
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-12       Impact factor: 9.236

5.  Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents: 18F-FAU, 18F-FMAU, and 18F-FLT.

Authors:  Christopher I McHugh; Jawana M Lawhorn-Crews; Dipenkumar Modi; Kirk A Douglas; Steven K Jones; Thomas J Mangner; Jerry M Collins; Anthony F Shields
Journal:  Cancer Imaging       Date:  2016-10-17       Impact factor: 3.909
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.