| Literature DB >> 12493537 |
Mikako Ogawa1, Kentaro Hatano, Shinya Oishi, Yasuhiro Kawasumi, Nobutaka Fujii, Michiya Kawaguchi, Ryuichiro Doi, Masayuki Imamura, Mikio Yamamoto, Keiichi Ajito, Takahiro Mukai, Hideo Saji, Kengo Ito.
Abstract
The association of the alpha(v)beta(3) integrin with tumor metastasis and tumor related angiogenesis has been suggested. Therefore, by imaging the alpha(v)beta(3) receptor with PET, information concerning the tumor status could be obtained. Cyclic peptides including the RGD sequence, were radiolabeled by direct electrophilic fluorination with [(18)F]AcOF. In tumor-bearing mice, the labeled peptides accumulated at the tumor with a high tumor to blood ratio. These findings suggest that an assessment of tumor characteristics may be obtained by using these (18)F-labeled peptides. Copyright 2002 Elsevier Science Inc.Entities:
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Year: 2003 PMID： 12493537 DOI： 10.1016/s0969-8051(02)00387-6
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408