Inhibition by prednisone of late cutaneous allergic responses induced by antiserum to human IgE.

Dual cutaneous allergic responses can be induced in human subjects by the intracutaneous injection of antiserum to human IgE (AHIGE). Adrenocortical steroid fails to inhibit the AHIGE-induced early wheal-and-flare response but does inhibit the late allergic response. This pattern of inhibition by adrenocortical steroid resembles that known to pertain to allergen-induced dual cutaneous allergic responses.