| Literature DB >> 12492704 |
Nathalie Rouas-Freiss1, Joël LeMaoult, Philippe Moreau, Jean Dausset, Edgardo D Carosella.
Abstract
The human MHC class I molecule HLA-G has long been known as a molecule selectively expressed by cytotrophoblastic cells. By inhibiting the cytolytic function of decidual NK cells, HLA-G protects the HLA-A and -B negative semiallogeneic embryonic tissue against the mother's immune system. In the light of this immuno-suppressive function, the role of HLA-G in transplantation was investigated. We will review here recently published data on this topic, showing that expression of HLA-G affects the responsive capacity of the immune system, might directly participate in graft acceptation, and should be taken into account for the monitoring of transplantation patients.Entities:
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Year: 2003 PMID： 12492704 DOI： 10.1034/j.1600-6143.2003.30103.x
Source DB: PubMed Journal: Am J Transplant ISSN： 1600-6135 Impact factor: 8.086