OBJECTIVE: To examine CD14 and TNFalpha gene polymorphisms in early arthritis in relation to clinical outcome. METHODS: We studied 141 Caucasians who had had early arthritis 10 to 38 years earlier. We analysed CD14 (-159) and TNFalpha (-238, -308, -376) polymorphisms using a novel cycle minisequencing method. DNA pools from 370 Caucasian blood donors served as controls. RESULTS: CD14 (-159)C-->T allele frequencies were comparable among patients and controls (39% vs 40%). Fifty men and 42 women had recovered while 24 men and six women had chronic spondyloarthropathy (SpA). Mutant T allele frequency was higher in the chronic SpA group than in the recovered group in women (75% vs 32%, relative risk 1.3, 95% confidence limit 1.1 to 1.6, P = 0.011), but not in men (38% vs 44%). All female patients with chronic SpA had CD14 (-159)T allele and none had a possibly protective TNFalpha (-308)G-->A allele. CONCLUSIONS: Possession of CD14 (-159)T allele does not increase risk of ReA but may increase susceptibility of female patients to development of chronic SpA.
OBJECTIVE: To examine CD14 and TNFalpha gene polymorphisms in early arthritis in relation to clinical outcome. METHODS: We studied 141 Caucasians who had had early arthritis 10 to 38 years earlier. We analysed CD14 (-159) and TNFalpha (-238, -308, -376) polymorphisms using a novel cycle minisequencing method. DNA pools from 370 Caucasian blood donors served as controls. RESULTS:CD14 (-159)C-->T allele frequencies were comparable among patients and controls (39% vs 40%). Fifty men and 42 women had recovered while 24 men and six women had chronic spondyloarthropathy (SpA). Mutant T allele frequency was higher in the chronic SpA group than in the recovered group in women (75% vs 32%, relative risk 1.3, 95% confidence limit 1.1 to 1.6, P = 0.011), but not in men (38% vs 44%). All female patients with chronic SpA had CD14 (-159)T allele and none had a possibly protective TNFalpha (-308)G-->A allele. CONCLUSIONS: Possession of CD14 (-159)T allele does not increase risk of ReA but may increase susceptibility of female patients to development of chronic SpA.
Authors: C Meiler; M Muhlbauer; M Johann; A Hartmann; B Schnabl; N Wodarz; G Schmitz; J Scholmerich; C Hellerbrand Journal: World J Gastroenterol Date: 2005-10-14 Impact factor: 5.742
Authors: K Kuuliala; A Orpana; M Leirisalo-Repo; H Kautiainen; M Hurme; P Hannonen; M Korpela; T Möttönen; L Paimela; K Puolakka; A Karjalainen; H Repo Journal: Ann Rheum Dis Date: 2006-04-10 Impact factor: 19.103
Authors: M van der Paardt; J B A Crusius; M H M T de Koning; S A Morré; R J van de Stadt; B A C Dijkmans; A S Peña; I E van der Horst-Bruinsma Journal: Ann Rheum Dis Date: 2005-02 Impact factor: 19.103
Authors: Sander Ouburg; Joke Spaargaren; Janneke E den Hartog; Jolande A Land; Johan S A Fennema; Jolein Pleijster; A Salvador Peña; Servaas A Morré Journal: BMC Infect Dis Date: 2005-12-20 Impact factor: 3.090