Literature DB >> 1249211

The biosynthesis of guanidinosuccinic acid by perfused rat liver.

G Perez, A Rey, E Schiff.   

Abstract

The metabolic pathway for the synthesis of guanidinosuccinic acid was studied in the rat. Labeled guanidinosuccinic acid was isolated from the urine of animals given L-[guanidino-14C]arginine intraperitoneally but did not appear in the urine after administration of D,L-[guanidino-14C]canavanine. Radioactive arginine and nonradioactive aspartic acid and arginine were infused in the isolated, perfused rat liver. After 20 min, small amounts of both labeled and unlabeled guanidinosuccinic acid and large amounts of urea were detected in radiochromatograms of the perfusate. These results support the theory that guanidinosuccinic acid is formed in the liver from transamidination of arginine to aspartic acid.

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Year:  1976        PMID： 1249211      PMCID： PMC436717          DOI： 10.1172/JCI108340

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  8 in total

1.  Metabolic control of creatine biosynthesis. I. Effect of dietary creatine.

Authors:  J B WALKER
Journal:  J Biol Chem       Date:  1960-08       Impact factor: 5.157

2.  The colorimetric determination of mono- and disubstituted guanidines.

Authors:  M J Micklus; I M Stein
Journal:  Anal Biochem       Date:  1973-08       Impact factor: 3.365

3.  Evidence that guanidines and some related compounds cause haemolysis in chronic uraemia.

Authors:  S Giovannetti; L Cioni; P L Balestri; M Biagnini
Journal:  Clin Sci       Date:  1968-02       Impact factor: 6.124

4.  Transketolase activity in uremia.

Authors:  E T Lonergan; M Semar; K Lange
Journal:  Arch Intern Med       Date:  1970-11

5.  Uremic toxins and platelet function.

Authors:  H I Horowitz
Journal:  Arch Intern Med       Date:  1970-11

6.  Guanidinosuccinic acid in uremia.

Authors:  B D Cohen
Journal:  Arch Intern Med       Date:  1970-11

7.  Guanidinosuccinic acid in renal failure, experimental azotemia and inborn errors of the urea cycle.

Authors:  I M Stein; B D Cohen; R S Kornhauser
Journal:  N Engl J Med       Date:  1969-04-24       Impact factor: 91.245

8.  Cleavage of canavaninosuccinic acid by human liver to form guanidinosuccinic acid, a substance found in the urine of uremic patients.

Authors:  K Takahara; S Nakanishi; S Natelson
Journal:  Clin Chem       Date:  1969-05       Impact factor: 8.327
  8 in total
  2 in total

Review 1.  Clinico-biochemical aspects of guanidine compounds in uraemic toxicity.

Authors:  B K Kishore; Z Kállay; P M Tulkens
Journal:  Int Urol Nephrol       Date:  1989       Impact factor: 2.370

2.  Effect of acute uremia on arginine metabolism and urea and guanidino acid production by perfused rat liver.

Authors:  G O Perez; B Rietberg; B Owens; E R Schiff
Journal:  Pflugers Arch       Date:  1977       Impact factor: 3.657
  2 in total

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