Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The core structure of TMC-95A is a promising lead for reversible proteasome inhibition.

× No keyword cloud information.

6 in total

1. A concise, total synthesis of the TMC-95A/B proteasome inhibitors.

Authors: Brian K Albrecht; Robert M Williams
Journal: Proc Natl Acad Sci U S A Date: 2004-05-26 Impact factor: 11.205

2. α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells.

Authors: Martina Bazzaro; Ravi K Anchoori; Mohana Krishna R Mudiam; Olga Issaenko; Srinivas Kumar; Balasubramanyam Karanam; Zhenhua Lin; Rachel Isaksson Vogel; Riccardo Gavioli; Federica Destro; Valeria Ferretti; Richard B S Roden; Saeed R Khan
Journal: J Med Chem Date: 2010-12-27 Impact factor: 7.446

3. Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition.

Authors: Jérôme Clerc; Michael Groll; Damir J Illich; André S Bachmann; Robert Huber; Barbara Schellenberg; Robert Dudler; Markus Kaiser
Journal: Proc Natl Acad Sci U S A Date: 2009-04-09 Impact factor: 11.205

The core structure of TMC-95A is a promising lead for reversible proteasome inhibition.

1. A concise, total synthesis of the TMC-95A/B proteasome inhibitors.

2. α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells.

3. Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition.

4. Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome.

5. Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors.

6. Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells.