Literature DB >> 12490885

Getting to the heart of a splicing enhancer.

Daniel Bilbao, Juan Valcárcel.   

Abstract

Dinucleotide CA repeats of variable length in an intron of the human endothelial nitric oxide synthase gene act as regulatory signals for splicing of the gene's pre-mRNA. Repeat length-dependent binding of hnRNP L to the repeats provides an intriguing link between splicing efficiency, nitric oxide synthesis and cardiovascular disease.

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Year:  2003        PMID： 12490885     DOI： 10.1038/nsb0103-6

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  4 in total

1.  Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing.

Authors:  Jingyi Hui; Lee-Hsueh Hung; Monika Heiner; Silke Schreiner; Norma Neumüller; Gregor Reither; Stefan A Haas; Albrecht Bindereif
Journal:  EMBO J       Date:  2005-05-12       Impact factor: 11.598

2.  Novel functional role of CA repeats and hnRNP L in RNA stability.

Authors:  Jingyi Hui; Gregor Reither; Albrecht Bindereif
Journal:  RNA       Date:  2003-08       Impact factor: 4.942

3.  A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2.

Authors:  Haihong Shen; Julie L C Kan; Claudia Ghigna; Giuseppe Biamonti; Michael R Green
Journal:  RNA       Date:  2004-05       Impact factor: 4.942

4.  Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis.

Authors:  Lee-Hsueh Hung; Monika Heiner; Jingyi Hui; Silke Schreiner; Vladimir Benes; Albrecht Bindereif
Journal:  RNA       Date:  2007-12-11       Impact factor: 4.942
  4 in total

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