Literature DB >> 12486604

A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.

M Ban1, G J Stewart, B H Bennetts, R Heard, R Simmons, M Maranian, A Compston, S J Sawcer.   

Abstract

The role of genetic factors in determining susceptibility to multiple sclerosis is well established but, despite the global distribution of the disease, systematic efforts to locate susceptibility genes have concentrated exclusively on populations from the Northern Hemisphere. We performed a genome wide screen of linkage in the Australian population using a panel of 397 microsatellite markers in 54 affected sibling-pairs. Multipoint linkage analysis revealed four regions of suggestive linkage (on chromosomes 2p13, 4q26-28, 6q26 and Xp11) and 18 additional regions of potential linkage (at 1q43-44, 3q13-24, 4q24, 4q31-34, 5q11-13, 6q27, 7q33-35, 8p23-21, 9q21, 13q31-32, 16p13, 16p11, 16q23-24, 17p13, 18p11, 20p12-11, Xp21-11 and Xq23-28). Our results contribute to the available data adding new provisional regions of linkage as well as increasing support for areas previously implicated in genetic susceptibility to multiple sclerosis.

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Year:  2002        PMID： 12486604     DOI： 10.1038/sj.gene.6363910

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


  12 in total

1.  A high-density screen for linkage in multiple sclerosis.

Authors:  Stephen Sawcer; Maria Ban; Mel Maranian; Tai Wai Yeo; Alastair Compston; Andrew Kirby; Mark J Daly; Philip L De Jager; Emily Walsh; Eric S Lander; John D Rioux; David A Hafler; Adrian Ivinson; Jacqueline Rimmler; Simon G Gregory; Silke Schmidt; Margaret A Pericak-Vance; Eva Akesson; Jan Hillert; Pameli Datta; Annette Oturai; Lars P Ryder; Hanne F Harbo; Anne Spurkland; Kjell-Morten Myhr; Mikko Laaksonen; David Booth; Robert Heard; Graeme Stewart; Robin Lincoln; Lisa F Barcellos; Stephen L Hauser; Jorge R Oksenberg; Shannon J Kenealy; Jonathan L Haines
Journal:  Am J Hum Genet       Date:  2005-07-29       Impact factor: 11.025

2.  Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice.

Authors:  Johan Ockinger; Pablo Serrano-Fernández; Steffen Möller; Saleh M Ibrahim; Tomas Olsson; Maja Jagodic
Journal:  Genetics       Date:  2006-04-19       Impact factor: 4.562

3.  Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis.

Authors:  Jian Rong Sheng; Maja Jagodic; Ingrid Dahlman; Kristina Becanovic; Rita Nohra; Monica Marta; Ellen Iacobaeus; Tomas Olsson; Erik Wallström
Journal:  Genetics       Date:  2005-02-16       Impact factor: 4.562

4.  The genetic aspects of multiple sclerosis.

Authors:  Stephen Sawcer
Journal:  Ann Indian Acad Neurol       Date:  2009-10       Impact factor: 1.383

5.  A second-generation genomic screen for multiple sclerosis.

Authors:  S J Kenealy; M-C Babron; Y Bradford; N Schnetz-Boutaud; J L Haines; J B Rimmler; S Schmidt; M A Pericak-Vance; L F Barcellos; R R Lincoln; J R Oksenberg; S L Hauser; M Clanet; D Brassat; G Edan; J Yaouanq; G Semana; I Cournu-Rebeix; O Lyon-Caen; B Fontaine
Journal:  Am J Hum Genet       Date:  2004-10-19       Impact factor: 11.025

6.  A genome-wide scan in forty large pedigrees with multiple sclerosis.

Authors:  Cristen J Willer; David A Dyment; Stacey Cherny; Sreeram V Ramagopalan; Blanca M Herrera; Katie M E Morrison; A Dessa Sadovnick; Neil J Risch; George C Ebers
Journal:  J Hum Genet       Date:  2007-11-15       Impact factor: 3.172

Review 7.  A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches.

Authors:  V V Bashinskaya; O G Kulakova; A N Boyko; A V Favorov; O O Favorova
Journal:  Hum Genet       Date:  2015-09-25       Impact factor: 4.132

8.  Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites.

Authors:  Sally John; Neil Shephard; Guoying Liu; Eleftheria Zeggini; Manqiu Cao; Wenwei Chen; Nisha Vasavda; Tracy Mills; Anne Barton; Anne Hinks; Steve Eyre; Keith W Jones; William Ollier; Alan Silman; Neil Gibson; Jane Worthington; Giulia C Kennedy
Journal:  Am J Hum Genet       Date:  2004-05-20       Impact factor: 11.025

9.  The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.

Authors:  G C DeLuca; S V Ramagopalan; M Z Cader; D A Dyment; B M Herrera; S Orton; A Degenhardt; M Pugliatti; A D Sadovnick; S Sotgiu; G C Ebers
Journal:  J Neurol       Date:  2007-04-10       Impact factor: 4.849

10.  Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

Authors:  J L McCauley; R L Zuvich; Y Bradford; S J Kenealy; N Schnetz-Boutaud; S G Gregory; S L Hauser; J R Oksenberg; D P Mortlock; M A Pericak-Vance; J L Haines
Journal:  Genes Immun       Date:  2009-07-23       Impact factor: 2.676
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