Literature DB >> 12485931

Intercellular adhesion molecule-1 in the heart.

Hans W M Niessen1, Paul A J Krijnen, Cees A Visser, Chris J L M Meijer, C Erik Hack.   

Abstract

Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

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Year:  2002        PMID： 12485931     DOI： 10.1111/j.1749-6632.2002.tb04703.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  8 in total

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