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Literature DB >> 12485871

Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells.

Katarzyna Piwocka¹, Anna Bielak-Mijewska, Ewa Sikora.

Abstract

Curcumin, the major component of the spice turmeric, used in 50- micro M concentration, induced cell death in multidrug-resistant CEM(P-gp4) and LoVo(P-gp4) cells as well as in their sensitive counterparts as assessed by TUNEL method and morphological observation. In all cells induced to undergo cell death with curcumin, there was no caspase-3 activation because only the unprocessed form of caspase-3 was observed using immunoblotting.

Entities: Chemical Gene Species

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Year: 2002 PMID： 12485871 DOI： 10.1111/j.1749-6632.2002.tb04643.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

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Cited

11 in total

1. P-glycoprotein is not involved in pathway of anti-Fas/Fas-induced apoptosis in KBv200 cells.

Authors: Qiu-Liang Wu; Xing-Ping Wu; Yong-Ju Liang; Li-Ming Chen; Yan Ding; Li-Wu Fu
Journal: World J Gastroenterol Date: 2005-06-21 Impact factor: 5.742

2. Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity.

Authors: A Bielak-Zmijewska; M Sikora-Polaczek; K Nieznanski; G Mosieniak; A Kolano; M Maleszewski; J Styrna; E Sikora
Journal: Cell Prolif Date: 2010-08 Impact factor: 6.831

3. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK.

Authors: Nathan M Weir; Karuppaiyah Selvendiran; Vijay Kumar Kutala; Liyue Tong; Shilpa Vishwanath; Murugesan Rajaram; Susheela Tridandapani; Shrikant Anant; Periannan Kuppusamy
Journal: Cancer Biol Ther Date: 2007-02-05 Impact factor: 4.742

Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells.

1. P-glycoprotein is not involved in pathway of anti-Fas/Fas-induced apoptosis in KBv200 cells.

2. Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity.

3. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK.

Review 4. Curcumin a potent cancer preventive agent: Mechanisms of cancer cell killing.

Review 5. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?

6. Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.

Review 7. Curcumin: from ancient medicine to current clinical trials.

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9. SC79 protects dopaminergic neurons from oxidative stress.

10. ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation.