Literature DB >> 12485859

Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis.

Sandrine Lépine1, Boris Lakatos, Pierre Maziere, Marie-Pierre Courageot, Jean-Claude Sulpice, Françoise Giraud.   

Abstract

It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone-induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase-dependent manner.

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Year:  2002        PMID: 12485859     DOI: 10.1111/j.1749-6632.2002.tb04631.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN: 0077-8923            Impact factor:   5.691


  5 in total

1.  Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.

Authors:  Francesca Cingolani; Fabio Simbari; Jose Luis Abad; Mireia Casasampere; Gemma Fabrias; Anthony H Futerman; Josefina Casas
Journal:  J Lipid Res       Date:  2017-06-01       Impact factor: 5.922

Review 2.  Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate.

Authors:  Cungui Mao; Lina M Obeid
Journal:  Biochim Biophys Acta       Date:  2008-06-13

3.  The role of skeletal muscle sphingolipids in the development of insulin resistance.

Authors:  Marek Straczkowski; Irina Kowalska
Journal:  Rev Diabet Stud       Date:  2008-05-10

Review 4.  Role of ceramide in diabetes mellitus: evidence and mechanisms.

Authors:  Sehamuddin Galadari; Anees Rahman; Siraj Pallichankandy; Alaa Galadari; Faisal Thayyullathil
Journal:  Lipids Health Dis       Date:  2013-07-08       Impact factor: 3.876

5.  Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.

Authors:  Ruijuan Xu; Monica Garcia-Barros; Sally Wen; Fang Li; Chih-Li Lin; Yusuf A Hannun; Lina M Obeid; Cungui Mao
Journal:  Cell Death Differ       Date:  2017-12-11       Impact factor: 15.828

  5 in total

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