Literature DB >> 12485836

Signaling pathways mediate the neuroprotective effects of GDNF.

F Neff1, C Noelker, K Eggert, J Schlegel.   

Abstract

We show that the glial cell line-derived neurotrophic factor (GDNF) activates the PI3K/Akt-signaling pathway in human neuroblastoma cells that express functional Ret-receptor complexes. Consistent with this finding we show PI3K-dependent Bad-inactivation by binding to 14-3-3 proteins in response to GDNF. Using differential display techniques we detected several cDNA clones differentially expressed after treatment with GDNF or 6-OHDA.

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Year:  2002        PMID： 12485836     DOI： 10.1111/j.1749-6632.2002.tb04608.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  5 in total

Review 1.  Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

Authors:  Carol Mackintosh
Journal:  Biochem J       Date:  2004-07-15       Impact factor: 3.857

2.  Neonatal Oxidative Stress Impairs Cortical Synapse Formation and GABA Homeostasis in Parvalbumin-Expressing Interneurons.

Authors:  Till Scheuer; Stefanie Endesfelder; Elena Auf dem Brinke; Christoph Bührer; Thomas Schmitz
Journal:  Oxid Med Cell Longev       Date:  2022-05-25       Impact factor: 7.310

3.  Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat Parkinsonism.

Authors:  Nga-Ping Lui; Liang-Wei Chen; Wing-Ho Yung; Ying-Shing Chan; Ken Kin-Lam Yung
Journal:  PLoS One       Date:  2012-12-12       Impact factor: 3.240

4.  The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.

Authors:  Raja Kittappa; Wendy W Chang; Rajeshwar B Awatramani; Ronald D G McKay
Journal:  PLoS Biol       Date:  2007-12       Impact factor: 8.029

5.  Molecular Mechanisms Responsible for Neuron-Derived Conditioned Medium (NCM)-Mediated Protection of Ischemic Brain.

Authors:  Chi-Hsin Lin; Chen-Hsuan Wang; Shih-Lan Hsu; Li-Ya Liao; Ting-An Lin; Chi-Mei Hsueh
Journal:  PLoS One       Date:  2016-01-08       Impact factor: 3.240
  5 in total

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