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Literature DB >> 12485829

The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion.

Thierry Fournier¹, Laetitia Pavan, Anne Tarrade, Kristina Schoonjans, Johan Auwerx, Cecile Rochette-Egly, Daniele Evain-Brion.

Abstract

PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by themselves and abolished PPAR-gamma agonist-mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.

Entities: Chemical Gene Species

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Year: 2002 PMID： 12485829 DOI： 10.1111/j.1749-6632.2002.tb04601.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

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Cited

18 in total

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4. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.

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The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion.

1. Genome-wide and candidate gene association studies of placental abruption.

2. FOSL1 is integral to establishing the maternal-fetal interface.

3. Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study.

4. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.

5. Nuclear Receptors in Pregnancy and Outcomes: Clinical Perspective.

6. Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma.

7. Combination Therapy of PPARgamma Ligands and Inhibitors of Arachidonic Acid in Lung Cancer.

8. Expression and Function of PPARs in Placenta.

Review 9. Role of the Peroxisome Proliferator Activated Receptors in Hypertension.

10. Placental implications of peroxisome proliferator-activated receptors in gestation and parturition.