Literature DB >> 12485350

Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens.

K Baert1, P De Backer.   

Abstract

Three nonsteroidal anti-inflammatory drugs (NSAIDs) [sodium salicylate, flunixin (FLU) and meloxicam (MEL)] were administered intravenously to broiler chickens. Plasma concentrations were determined by high-performance liquid chromatography methods and pharmacokinetic parameters were calculated. After intravenous administration of sodium salicylate (50 mg/kg), FLU (1.1 mg/kg) and MEL (0.5 mg/kg), these drugs were eliminated from plasma with a mean half-life of 04.04, 05.45 and 03.20 h, respectively. Apparent volumes of distribution (0.39, 0.08 and 0.12 L/kg, respectively) indicated that tissue distribution was limited for the three drugs. Total body clearance was 70 mL/h.kg for sodium salicylate and 10 and 25 mL/kg.h for FLU and MEL, respectively. Based on the pharmacokinetic parameters these NSAIDs may offer possibilities for treatment of various conditions in chickens.

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Year:  2002        PMID： 12485350     DOI： 10.1046/j.1365-2885.2002.00441.x

Source DB:  PubMed          Journal:  J Vet Pharmacol Ther        ISSN： 0140-7783            Impact factor:   1.786


  8 in total

1.  Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits.

Authors:  M Elmas; E Yazar; K Uney; A Karabacak
Journal:  Vet Res Commun       Date:  2006-01       Impact factor: 2.459

2.  Pharmacokinetics of 3 formulations of meloxicam in cynomolgus macaques (Macaca fascicularis).

Authors:  Cassondra Bauer; Patrice Frost; Stephen Kirschner
Journal:  J Am Assoc Lab Anim Sci       Date:  2014-09       Impact factor: 1.232

3.  Aqueous stability and oral pharmacokinetics of meloxicam and carprofen in male C57BL/6 mice.

Authors:  Joelle C Ingrao; Ron Johnson; Elizabeth Tor; Yu Gu; Marcus Litman; Patricia V Turner
Journal:  J Am Assoc Lab Anim Sci       Date:  2013-09       Impact factor: 1.232

4.  Dexamethasone reduces infectious bursal disease mortality in chickens.

Authors:  Seung Yub Shin; Tae Hee Han; Hyuk Joon Kwon; Sun Joong Kim; Pan Dong Ryu
Journal:  J Vet Sci       Date:  2021-03-23       Impact factor: 1.672

5.  Pharmacokinetics of repeated sodium salicylate administration to laying hens: evidence for time dependent increase in drug elimination from plasma and eggs.

Authors:  Błażej Poźniak; Tomasz Grabowski; Karolina Motykiewicz-Pers; Kamila Bobrek; Lech Rak; Katarzyna Bobusia; Andrzej Gaweł; Marcin Świtała
Journal:  PLoS One       Date:  2015-04-20       Impact factor: 3.240

6.  Thermal nociception as a measure of non-steroidal anti-inflammatory drug effectiveness in broiler chickens with articular pain.

Authors:  Gina Caplen; Laurence Baker; Becky Hothersall; Dorothy E F McKeegan; Victoria Sandilands; Nick H C Sparks; Avril E Waterman-Pearson; Joanna C Murrell
Journal:  Vet J       Date:  2013-09-20       Impact factor: 2.688

7.  Pharmacokinetics of Salicylic Acid Following Intravenous and Oral Administration of Sodium Salicylate in Sheep.

Authors:  Shashwati Mathurkar; Preet Singh; Kavitha Kongara; Paul Chambers
Journal:  Animals (Basel)       Date:  2018-07-18       Impact factor: 2.752

8.  Pharmacokinetic Parameters and Estimating Extra-Label Tissue Withdrawal Intervals Using Three Approaches and Various Matrices for Domestic Laying Chickens Following Meloxicam Administration.

Authors:  Emily D Richards; Rachel S Dutch; Nathaniel C Burmas; Jennifer L Davis; Zhoumeng Lin; Maaike O Clapham; Scott E Wetzlich; Lisa A Tell
Journal:  Front Vet Sci       Date:  2022-03-03
  8 in total

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