Literature DB >> 12482725

The pharmacology of gastrointestinal nociceptive pathways.

L A Blackshaw1, G F Gebhart.   

Abstract

The principal conscious sensations that arise from the gastrointestinal tract are discomfort and pain. Chronic visceral discomfort and pain are generally managed poorly with currently available pharmacological agents. Receptors and ion channels present on extrinsic visceral primary afferent (sensory) neurons are targets for the development of new pharmacological strategies for control of visceral pain.

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Year:  2002        PMID： 12482725     DOI： 10.1016/s1471-4892(02)00211-4

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  25 in total

1.  Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve.

Authors:  H U De Schepper; J G De Man; L Van Nassauw; J-P Timmermans; A G Herman; P A Pelckmans; B Y De Winter
Journal:  Gut       Date:  2006-09-14       Impact factor: 23.059

2.  'Spotting' afferent pathways of hindgut sensations - role of endothelin-3 signalling.

Authors:  Michael J Beyak
Journal:  J Physiol       Date:  2011-05-15       Impact factor: 5.182

3.  Hyperpolarization-activated cyclic nucleotide-gated cation channel subtypes differentially modulate the excitability of murine small intestinal afferents.

Authors:  Ying-Ping Wang; Bi-Ying Sun; Qian Li; Li Dong; Guo-Hua Zhang; David Grundy; Wei-Fang Rong
Journal:  World J Gastroenterol       Date:  2012-02-14       Impact factor: 5.742

Review 4.  Extrinsic primary afferent signalling in the gut.

Authors:  Simon J H Brookes; Nick J Spencer; Marcello Costa; Vladimir P Zagorodnyuk
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2013-02-26       Impact factor: 46.802

5.  Electroacupuncture alleviates stress-induced visceral hypersensitivity through an opioid system in rats.

Authors:  Yuan-Yuan Zhou; Natalie J Wanner; Ying Xiao; Xuan-Zheng Shi; Xing-Hong Jiang; Jian-Guo Gu; Guang-Yin Xu
Journal:  World J Gastroenterol       Date:  2012-12-28       Impact factor: 5.742

6.  Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression.

Authors:  D J Schuster; J A Dykstra; M S Riedl; K F Kitto; C N Honda; R S McIvor; C A Fairbanks; L Vulchanova
Journal:  Neurogastroenterol Motil       Date:  2012-12-18       Impact factor: 3.598

7.  Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model.

Authors:  Matthew M Smiley; Ying Lu; Louis P Vera-Portocarrero; Amr Zidan; Karin N Westlund
Journal:  Anesthesiology       Date:  2004-09       Impact factor: 7.892

8.  Selective role for TRPV4 ion channels in visceral sensory pathways.

Authors:  Stuart M Brierley; Amanda J Page; Patrick A Hughes; Birgit Adam; Tobias Liebregts; Nicole J Cooper; Gerald Holtmann; Wolfgang Liedtke; L Ashley Blackshaw
Journal:  Gastroenterology       Date:  2008-01-31       Impact factor: 22.682

9.  Nitric oxide as an endogenous peripheral modulator of visceral sensory neuronal function.

Authors:  Amanda J Page; Tracey A O'Donnell; Nicole J Cooper; Richard L Young; L Ashley Blackshaw
Journal:  J Neurosci       Date:  2009-06-03       Impact factor: 6.167

Review 10.  Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome.

Authors:  James J Galligan
Journal:  Br J Pharmacol       Date:  2004-03-29       Impact factor: 8.739
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