Literature DB >> 12482526

Monoclonal antibody manufacturing in transgenic plants--myths and realities.

Elizabeth E Hood1, Susan L Woodard, Michael E Horn.   

Abstract

The number and types of antibodies expressed in plants has increased steadily since the first reports of this accomplishment in the 1980s, illustrating the versatility of plants as a production system for antibodies. Many recent reviews have detailed the antibody forms that have been derived from plant expression systems. This contribution focuses on the remaining challenges to develop plant-derived therapeutic antibodies into products, and some of the progress that is being made in addressing these challenges.

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Year:  2002        PMID： 12482526     DOI： 10.1016/s0958-1669(02)00351-8

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  30 in total

1.  Translational fusion and redirection to thylakoid lumen as strategies to improve the accumulation of a camelid antibody fragment in transplastomic tobacco.

Authors:  Ezequiel M Lentz; Lorena Garaicoechea; E Federico Alfano; Viviana Parreño; Andrés Wigdorovitz; Fernando F Bravo-Almonacid
Journal:  Planta       Date:  2012-04-24       Impact factor: 4.116

2.  Rhizobia species: A Boon for "Plant Genetic Engineering".

Authors:  Urmi Patel; Sarika Sinha
Journal:  Indian J Microbiol       Date:  2011-02-26       Impact factor: 2.461

3.  Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells.

Authors:  Helga Schinkel; Andreas Schiermeyer; Raphael Soeur; Rainer Fischer; Stefan Schillberg
Journal:  Transgenic Res       Date:  2005-06       Impact factor: 2.788

4.  Expression of a staphylokinase, a thrombolytic agent in Arabidopsis thaliana.

Authors:  Aneta Wiktorek-Smagur; Katarzyna Hnatuszko-Konka; Aneta Gerszberg; Aneta Geszberg; Piotr Luchniak; Tomasz Kowalczyk; Andrzej K Kononowicz
Journal:  World J Microbiol Biotechnol       Date:  2010-10-23       Impact factor: 3.312

5.  Tobacco ribosomal DNA spacer element elevates Bowman-Birk inhibitor expression in tomato plants.

Authors:  Nir Yakoby; Alison Garvey; Ilya Raskin
Journal:  Plant Cell Rep       Date:  2006-01-12       Impact factor: 4.570

Review 6.  Anti-Ebola therapies based on monoclonal antibodies: current state and challenges ahead.

Authors:  Everardo González-González; Mario Moisés Alvarez; Alan Roberto Márquez-Ipiña; Grissel Trujillo-de Santiago; Luis Mario Rodríguez-Martínez; Nasim Annabi; Ali Khademhosseini
Journal:  Crit Rev Biotechnol       Date:  2015-11-26       Impact factor: 8.429

7.  Challenges in electrochemical pre-purification of recombinant proteins from green plant tissues: sgfp produced in tobacco leaves.

Authors:  Goran Robić
Journal:  Bioengineered       Date:  2012-03-01       Impact factor: 3.269

8.  Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

Authors:  Koreen Ramessar; Thomas Rademacher; Markus Sack; Johannes Stadlmann; Dimitris Platis; Gabriela Stiegler; Nikos Labrou; Fritz Altmann; Julian Ma; Eva Stöger; Teresa Capell; Paul Christou
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-03       Impact factor: 11.205

9.  High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system.

Authors:  Zhong Huang; Waranyoo Phoolcharoen; Huafang Lai; Khanrat Piensook; Guy Cardineau; Larry Zeitlin; Kevin J Whaley; Charles J Arntzen; Hugh S Mason; Qiang Chen
Journal:  Biotechnol Bioeng       Date:  2010-05-01       Impact factor: 4.530

Review 10.  Progress and challenges in the vaccine-based treatment of head and neck cancers.

Authors:  Aldo Venuti
Journal:  J Exp Clin Cancer Res       Date:  2009-05-27
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