Literature DB >> 12482428

Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action.

Hiroshi Shimoda1, Kiyofumi Ninomiya, Norihisa Nishida, Tomoe Yoshino, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa.   

Abstract

The methanolic extract from the leaves of artichoke (Cynara scolymus L.) was found to suppress serum triglyceride elevation in olive oil-loaded mice. Through bioassay-guided separation, sesquiterpenes (cynaropicrin, aguerin B, and grosheimin) were isolated as the active components together with new sesquiterpene glycosides (cynarascolosides A, B, and C). The oxygen functional groups at the 3- and 8-positions and exo-methylene moiety in alpha-methylene-gamma-butyrolactone ring were found to be essential for the anti-hyperlipidemic activity of guaiane-type sesquiterpene. In addition, inhibition of gastric emptying was shown to be partly involved in anti-hyperlipidemic activity.

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Year:  2003        PMID： 12482428     DOI： 10.1016/s0960-894x(02)00889-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  19 in total

1.  Novel hydroxycinnamoyl-coenzyme A quinate transferase genes from artichoke are involved in the synthesis of chlorogenic acid.

Authors:  Gabriella Sonnante; Rosalinda D'Amore; Emanuela Blanco; Ciro L Pierri; Monica De Palma; Jie Luo; Marina Tucci; Cathie Martin
Journal:  Plant Physiol       Date:  2010-04-29       Impact factor: 8.340

2.  Haplotype analysis of the germacrene A synthase gene and association with cynaropicrin content and biological activities in Cynara cardunculus.

Authors:  Ana Margarida Ferro; Patrícia Ramos; Ângela Guerra; Paula Parreira; Teresa Brás; Olinda Guerreiro; Eliana Jerónimo; Carmen Capel; Juan Capel; Fernando J Yuste-Lisbona; Maria F Duarte; Rafael Lozano; M Margarida Oliveira; Sónia Gonçalves
Journal:  Mol Genet Genomics       Date:  2017-11-16       Impact factor: 3.291

3.  Cynara scolymus leaves extract alleviates nandrolone decanoate-induced alterations in testicular function and sperm quality in albino rats.

Authors:  Eman Taha Mohammed; Abeer M Radi; Lotfi Aleya; Mohamed M Abdel-Daim
Journal:  Environ Sci Pollut Res Int       Date:  2019-12-16       Impact factor: 4.223

4.  Genetic map of artichoke × wild cardoon: toward a consensus map for Cynara cardunculus.

Authors:  Gabriella Sonnante; Angela Gatto; Anita Morgese; Francesco Montemurro; Giulio Sarli; Emanuela Blanco; Domenico Pignone
Journal:  Theor Appl Genet       Date:  2011-07-29       Impact factor: 5.699

5.  Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.

Authors:  Akifumi Nagatomo; Naoki Inoue; Takuya Konno; Yin Xu; Chinatsu Sakamoto; Mayuko Sone; Aya Shibasaka; Osamu Muraoka; Kiyofumi Ninomiya; Masayuki Yoshikawa; Yoshiaki Manse; Toshio Morikawa
Journal:  J Nat Med       Date:  2022-03-15       Impact factor: 2.343

6.  Pan-genotypic Hepatitis C Virus Inhibition by Natural Products Derived from the Wild Egyptian Artichoke.

Authors:  Mahmoud Fahmi Elsebai; George Koutsoudakis; Verónica Saludes; Gemma Pérez-Vilaró; Ari Turpeinen; Sampo Mattila; Anna Maria Pirttilä; Fabien Fontaine-Vive; Mohamed Mehiri; Andreas Meyerhans; Juana Diez
Journal:  J Virol       Date:  2015-12-09       Impact factor: 5.103

7.  RAD tag sequencing as a source of SNP markers in Cynara cardunculus L.

Authors:  Davide Scaglione; Alberto Acquadro; Ezio Portis; Matteo Tirone; Steven J Knapp; Sergio Lanteri
Journal:  BMC Genomics       Date:  2012-01-03       Impact factor: 3.969

8.  Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice.

Authors:  Hiroshi Shimoda; Emi Seki; Michio Aitani
Journal:  BMC Complement Altern Med       Date:  2006-03-17       Impact factor: 3.659

9.  Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster.

Authors:  Laura Vicedo Jacociunas; Rafael Rodrigues Dihl; Mauricio Lehmann; Alexandre de Barros Falcão Ferraz; Marc François Richter; Juliana da Silva; Heloísa Helena Rodrigues de Andrade
Journal:  Genet Mol Biol       Date:  2013-02-28       Impact factor: 1.771

10.  The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis.

Authors:  Vajiheh Rangboo; Mostafa Noroozi; Roza Zavoshy; Seyed Amirmansoor Rezadoost; Asghar Mohammadpoorasl
Journal:  Int J Hepatol       Date:  2016-05-11
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