| Literature DB >> 12482419 |
Ian Churcher1, Kate Ashton, John W Butcher, Earl E Clarke, Timothy Harrison, Huw D Lewis, Andrew P Owens, Martin R Teall, Susie Williams, Jonathan D J Wrigley.
Abstract
A new series of benzodiazepine-containing gamma-secretase inhibitors with potential use in the treatment of Alzheimer's disease is disclosed. Structure-activity relationships of the pendant hydrocinnamate side-chain which led to the preparation of highly potent inhibitors are described.Entities:
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Year: 2003 PMID： 12482419 DOI： 10.1016/s0960-894x(02)00909-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823