Literature DB >> 12478722

Aziridines and aziridinium ions in the practical synthesis of pharmaceutical intermediates--a perspective.

Vilas H Dahanukar1, Ilia A Zavialov.   

Abstract

Recent methods for the synthesis of aziridines and aziridinium ions, the mechanisms of their nucleophilic ring-opening reactions and applications to the practical synthesis of pharmaceutical intermediates are reviewed.

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Year:  2002        PMID： 12478722

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  5 in total

1.  Selectivity in the addition reactions of organometallic reagents to aziridine-2-carboxaldehydes: the effects of protecting groups and substitution patterns.

Authors:  Aman Kulshrestha; Jennifer M Schomaker; Daniel Holmes; Richard J Staples; James E Jackson; Babak Borhan
Journal:  Chemistry       Date:  2011-09-16       Impact factor: 5.236

2.  Rh2(II)-Catalyzed Intermolecular N-Aryl Aziridination of Olefins Using Nonactivated N Atom Precursors.

Authors:  Tianning Deng; Wrickban Mazumdar; Yuki Yoshinaga; Pooja B Patel; Dana Malo; Tala Malo; Donald J Wink; Tom G Driver
Journal:  J Am Chem Soc       Date:  2021-11-08       Impact factor: 15.419

3.  Scope and mechanism of intramolecular aziridination of cyclopent-3-enyl-methylamines to 1-azatricyclo[2.2.1.0(2,6)]heptanes with lead tetraacetate.

Authors:  Huayou Hu; Juan A Faraldos; Robert M Coates
Journal:  J Am Chem Soc       Date:  2009-08-26       Impact factor: 15.419

4.  Synthesis of β-substituted tryptamines by regioselective ring opening of aziridines.

Authors:  Jesse Kidd; Kristen Maiden; Jeremy B Morgan
Journal:  Tetrahedron       Date:  2016-06-30       Impact factor: 2.457

5.  Palladium-Catalyzed, Enantioselective Desymmetrization of N-Acylaziridines with Indoles.

Authors:  Kinney Van Hecke; Tyler R Benton; Michael Casper; Dustin Mauldin; Brandon Drake; Jeremy B Morgan
Journal:  Org Lett       Date:  2021-10-05       Impact factor: 6.072
  5 in total

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