Literature DB >> 12478718

Synthetic applications of chiral 2,3-dihydro-4-pyridones.

Sajan Joseph1, Daniel L Comins.   

Abstract

During the last decade, 2,3-dihydro-4-pyridones have become important intermediates for the synthesis of various alkaloids and biologically active compounds. The versatility of these heterocyclic building blocks has been demonstrated by the synthesis of several complex natural products. This review will cover recent work on the synthesis of substituted dihydropyridones, and their application in the synthesis of complex molecules.

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Year:  2002        PMID: 12478718

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN: 1367-6733


  9 in total

1.  Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component.

Authors:  Hajime Seki; Gunda I Georg
Journal:  European J Org Chem       Date:  2014-06-01

2.  Organometallic enantiomeric scaffolding: a strategy for the enantiocontrolled construction of regio- and stereodivergent trisubstituted piperidines from a common precursor.

Authors:  Heilam Wong; Ethel C Garnier-Amblard; Lanny S Liebeskind
Journal:  J Am Chem Soc       Date:  2011-04-22       Impact factor: 15.419

3.  Three-component synthesis of cyclic enaminones via ketene cyclization.

Authors:  Hajime Seki; Gunda I Georg
Journal:  Org Lett       Date:  2011-04-01       Impact factor: 6.005

4.  Synthesis of amino acid derived enaminones via Wolff rearrangement using vinylogous amides as carbon nucleophiles.

Authors:  Hajime Seki; Gunda I Georg
Journal:  J Am Chem Soc       Date:  2010-11-10       Impact factor: 15.419

5.  Practical, scalable, high-throughput approaches to eta3-pyranyl and eta3-pyridinyl organometallic enantiomeric scaffolds using the Achmatowicz reaction.

Authors:  Thomas C Coombs; Maurice D Lee; Heilam Wong; Matthew Armstrong; Bo Cheng; Wenyong Chen; Alessandro F Moretto; Lanny S Liebeskind
Journal:  J Org Chem       Date:  2008-01-03       Impact factor: 4.354

6.  Enantioselective rhodium-catalyzed [2 + 2 + 2] cycloadditions of terminal alkynes and alkenyl isocyanates: mechanistic insights lead to a unified model that rationalizes product selectivity.

Authors:  Derek M Dalton; Kevin M Oberg; Robert T Yu; Ernest E Lee; Stéphane Perreault; Mark Emil Oinen; Melissa L Pease; Guillaume Malik; Tomislav Rovis
Journal:  J Am Chem Soc       Date:  2009-11-04       Impact factor: 15.419

7.  N-acyldihydropyridones as synthetic intermediates. A stereoselective synthesis of acyclic amino alcohols containing multiple chiral centers.

Authors:  W Stephen McCall; Teresa Abad Grillo; Daniel L Comins
Journal:  J Org Chem       Date:  2008-12-19       Impact factor: 4.354

8.  Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis.

Authors:  Yong Wook Kim; Gunda I Georg
Journal:  Org Lett       Date:  2014-03-03       Impact factor: 6.005

9.  Synthesis of the benzo-fused indolizidine alkaloid mimics.

Authors:  Daniel L Comins; Kazuhiro Higuchi
Journal:  Beilstein J Org Chem       Date:  2007-11-30       Impact factor: 2.883

  9 in total

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