Literature DB >> 12477747

HLA-DQ8 as an Ir gene in coeliac disease.

K E A Lundin1.   

Abstract

DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease

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Year:  2003        PMID： 12477747      PMCID： PMC1773536          DOI： 10.1136/gut.52.1.7

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  5 in total

1.  T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase.

Authors:  O Molberg; S McAdam; K E Lundin; C Kristiansen; H Arentz-Hansen; K Kett; L M Sollid
Journal:  Eur J Immunol       Date:  2001-05       Impact factor: 5.532

Review 2.  Molecular basis of celiac disease.

Authors:  L M Sollid
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

3.  The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides.

Authors:  S Buus; A Sette; S M Colon; C Miles; H M Grey
Journal:  Science       Date:  1987-03-13       Impact factor: 47.728

4.  An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients.

Authors:  G Mazzarella; M Maglio; F Paparo; G Nardone; R Stefanile; L Greco; Y van de Wal; Y Kooy; F Koning; S Auricchio; R Troncone
Journal:  Gut       Date:  2003-01       Impact factor: 23.059

Review 5.  Histocompatibility-linked immune response genes.

Authors:  B Benacerraf; H O McDevitt
Journal:  Science       Date:  1972-01-21       Impact factor: 47.728
  5 in total

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