| Literature DB >> 12477366 |
Miguel F Braña1, Mónica Cacho, Mario A García, Beatriz de Pascual-Teresa, Ana Ramos, Nuria Acero, Francisco Llinares, Dolores Muñoz-Mingarro, Cristina Abradelo, María Fernanda Rey-Stolle, Mercedes Yuste.
Abstract
A series of mono and bisintercalators based on the 5,8-dihydrobenz[de]imidazo[4,5-g]isoquinoline-4,6-dione system were synthesized and evaluated for growth inhibitory properties in several human cell lines. All target compounds showed activity in the micromolar range. Representative compounds were evaluated using UV--vis spectroscopy and viscosimetric determinations, showing that they behave as DNA intercalators. Molecular modeling techniques were used in order to rationalize the moderate activity observed for bisnaphthalimides.Entities:
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Year: 2002 PMID： 12477366 DOI： 10.1021/jm020950q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446