OBJECTIVE: To test the hypothesis that the screening-detected prevalence of prostate cancer is higher among men of African descent than among men of Asian-Indian descent living in Trinidad & Tobago. DESIGN: Population-based prostate cancer screening study among men aged 50-64. SETTING: Caribbean islands of Trinidad and Tobago. PARTICIPANTS: Tobago, population-based sample of 1196 male residents of African descent; Trinidad, 173 agricultural workers of Asian-Indian descent. INTERVENTIONS: Serum prostate specific antigen (PSA, Abbot AxSYM) and digital rectal exam (DRE) were used to screen men for prostate cancer. Men with elevated PSA (> or = 4 ng/mL) and/or abnormal DRE were offered an ultrasound guided sextant biopsy of the prostate gland. MAIN OUTCOME MEASURES: Prevalence of abnormal screen; prevalence of prostate cancer. RESULTS: Elevated PSA and/or abnormal DRE were observed in 29% (348/1196) of Afro-Tobagonian men. Three hundred sixteen men underwent biopsies. Screening-detected prostate cancer prevalence was: 4.9% (23/468) for those aged 50-55; 7.7% (28/366) for those aged 55-59; and 13.3% (48/362) for those aged 60-64 years. Screening was abnormal in 18% (31/173) of Asian-Indian men; 25 underwent biopsies. Prostate cancer prevalence in Asian Indian men was: 1.6% (1/63) for those aged 50-54; 1.4% (1/71) for those aged 55-59; and 5.1% (2/39) for those aged 60-64 years. Mantel-Haenszel age-adjusted rate ratio was 3.4, 95% CI 1.3-9.0. CONCLUSIONS: This study establishes a high prevalence of screening-detected prostate cancer among Afro-Tobagonians compared with Indo-Trinidadians. Comparison of candidate genes, environmental, and lifestyle factors between these populations may identify factors that increase risk for, or provide protection against, prostate cancer.
OBJECTIVE: To test the hypothesis that the screening-detected prevalence of prostate cancer is higher among men of African descent than among men of Asian-Indian descent living in Trinidad & Tobago. DESIGN: Population-based prostate cancer screening study among men aged 50-64. SETTING: Caribbean islands of Trinidad and Tobago. PARTICIPANTS: Tobago, population-based sample of 1196 male residents of African descent; Trinidad, 173 agricultural workers of Asian-Indian descent. INTERVENTIONS: Serum prostate specific antigen (PSA, Abbot AxSYM) and digital rectal exam (DRE) were used to screen men for prostate cancer. Men with elevated PSA (> or = 4 ng/mL) and/or abnormal DRE were offered an ultrasound guided sextant biopsy of the prostate gland. MAIN OUTCOME MEASURES: Prevalence of abnormal screen; prevalence of prostate cancer. RESULTS: Elevated PSA and/or abnormal DRE were observed in 29% (348/1196) of Afro-Tobagonian men. Three hundred sixteen men underwent biopsies. Screening-detected prostate cancer prevalence was: 4.9% (23/468) for those aged 50-55; 7.7% (28/366) for those aged 55-59; and 13.3% (48/362) for those aged 60-64 years. Screening was abnormal in 18% (31/173) of Asian-Indian men; 25 underwent biopsies. Prostate cancer prevalence in Asian Indian men was: 1.6% (1/63) for those aged 50-54; 1.4% (1/71) for those aged 55-59; and 5.1% (2/39) for those aged 60-64 years. Mantel-Haenszel age-adjusted rate ratio was 3.4, 95% CI 1.3-9.0. CONCLUSIONS: This study establishes a high prevalence of screening-detected prostate cancer among Afro-Tobagonians compared with Indo-Trinidadians. Comparison of candidate genes, environmental, and lifestyle factors between these populations may identify factors that increase risk for, or provide protection against, prostate cancer.
Authors: Yahtyng Sheu; Jane A Cauley; Clareann H Bunker; Victor W Wheeler; Alan L Patrick; Christopher L Gordon; Candace M Kammerer; Joseph M Zmuda Journal: J Bone Miner Res Date: 2009-12 Impact factor: 6.741
Authors: Jill D Henning; Jaideep M Karamchandani; Luis A Bonachea; Clareann H Bunker; Alan L Patrick; Frank J Jenkins Journal: Prostate Date: 2017-01-24 Impact factor: 4.104
Authors: Folakemi T Odedina; Daohai Yu; Titilola O Akinremi; R Renee Reams; Matthew L Freedman; Nagi Kumar Journal: J Immigr Minor Health Date: 2008-12-04
Authors: Charnita M Zeigler-Johnson; Hanna Rennert; R Devi Mittal; Mohamed Jalloh; Rajeev Sachdeva; S Bruce Malkowicz; Anil Mandhani; B Mittal; Serigne M Gueye; Timothy R Rebbeck Journal: Can J Urol Date: 2008-06 Impact factor: 1.344
Authors: Giorgio Sirugo; Branwen J Hennig; Adebowale A Adeyemo; Alice Matimba; Melanie J Newport; Muntaser E Ibrahim; Kelli K Ryckman; Alessandra Tacconelli; Renato Mariani-Costantini; Giuseppe Novelli; Himla Soodyall; Charles N Rotimi; Raj S Ramesar; Sarah A Tishkoff; Scott M Williams Journal: Hum Genet Date: 2008-05-30 Impact factor: 4.132
Authors: Charnita M Zeigler-Johnson; Elaine Spangler; Mohamed Jalloh; Serigne M Gueye; Hanna Rennert; Timothy R Rebbeck Journal: Can J Urol Date: 2008-02 Impact factor: 1.344
Authors: Yahtyng Sheu; Jane A Cauley; Victor W Wheeler; Alan L Patrick; Clareann H Bunker; Candace M Kammerer; Joseph M Zmuda Journal: J Bone Miner Res Date: 2009-07 Impact factor: 6.741