OBJECTIVE: To explore the molecular genetic relationship between chromosome 1 and susceptibility genes for familial schizophrenia in Chinese population. METHODS: A genome scanning was conducted in 32 multiplex pedigrees from Chinese population by using 29 microsatellite markers on chromosome 1. RESULTS: Multipoint parametric analysis detected a maximum heterogenicity Lod of 1.70 at 262.52 cM under a recessive model; multipoint non-parametric analysis detected a maximum non-parameter linkage (NPL) of 1.71 (P=0.046) at 262.52 cM, then 1.37 (P=0.086) at 149.70 cM, corresponding to marker D1S206 and D1S425 respectively. CONCLUSION: These results give further supports to the presence of susceptibility genes on chromosome 1q for familial schizophrenia.
OBJECTIVE: To explore the molecular genetic relationship between chromosome 1 and susceptibility genes for familial schizophrenia in Chinese population. METHODS: A genome scanning was conducted in 32 multiplex pedigrees from Chinese population by using 29 microsatellite markers on chromosome 1. RESULTS: Multipoint parametric analysis detected a maximum heterogenicity Lod of 1.70 at 262.52 cM under a recessive model; multipoint non-parametric analysis detected a maximum non-parameter linkage (NPL) of 1.71 (P=0.046) at 262.52 cM, then 1.37 (P=0.086) at 149.70 cM, corresponding to marker D1S206 and D1S425 respectively. CONCLUSION: These results give further supports to the presence of susceptibility genes on chromosome 1q for familial schizophrenia.
Authors: Richard Delorme; Catalina Betancur; Isabelle Scheid; Henrik Anckarsäter; Pauline Chaste; Stéphane Jamain; Franck Schuroff; Gudrun Nygren; Evelyn Herbrecht; Anne Dumaine; Marie Christine Mouren; Maria Råstam; Marion Leboyer; Christopher Gillberg; Thomas Bourgeron Journal: BMC Med Genet Date: 2010-07-05 Impact factor: 2.103
Authors: Xingqun Ni; Jose Valente; Maria H Azevedo; Michelle T Pato; Carlos N Pato; James L Kennedy Journal: J Med Genet Date: 2007-04-05 Impact factor: 6.318