Joanne L Wright1, Andrew Churg. 1. Department of Pathology, University of British Columbia, Vancouver, BC, Canada. jlwright@interchange.ubc.ca
Abstract
OBJECTIVES: To review the animal models of COPD, and to compare these data to those found in humans. RESULTS: Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of human emphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degree and/or presence of these different abnormalities, so that care has to be used in selecting a species to study. Remarkably little information is available about the biochemical and molecular changes induced by cigarette smoke in animal models. CONCLUSIONS: Great insights into the pathology of chronic obstructive lung disease have been made using various animal models.
OBJECTIVES: To review the animal models of COPD, and to compare these data to those found in humans. RESULTS: Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of humanemphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degree and/or presence of these different abnormalities, so that care has to be used in selecting a species to study. Remarkably little information is available about the biochemical and molecular changes induced by cigarette smoke in animal models. CONCLUSIONS: Great insights into the pathology of chronic obstructive lung disease have been made using various animal models.
Authors: Ching-Wen Wu; Tammy Yau; Ciara C Fulgar; Savannah M Mack; Alina M Revilla; Nicholas J Kenyon; Kent E Pinkerton Journal: Toxicol Pathol Date: 2019-12-24 Impact factor: 1.902
Authors: M A Hassan Talukder; Wesley M Johnson; Saradhadevi Varadharaj; Jiarui Lian; Patrick N Kearns; Mohamed A El-Mahdy; Xiaoping Liu; Jay L Zweier Journal: Am J Physiol Heart Circ Physiol Date: 2010-11-05 Impact factor: 4.733
Authors: I Mark Olfert; Evan DeVallance; Hannah Hoskinson; Kayla W Branyan; Stuart Clayton; Christopher R Pitzer; D Patrick Sullivan; Matthew J Breit; Zhongxin Wu; Powsiri Klinkhachorn; W Kyle Mandler; Brett H Erdreich; Barbara S Ducatman; Randall W Bryner; Piyali Dasgupta; Paul D Chantler Journal: J Appl Physiol (1985) Date: 2017-11-02
Authors: Carla M T Bauer; Caleb C J Zavitz; Fernando M Botelho; Kristen N Lambert; Earl G Brown; Karen L Mossman; John D Taylor; Martin R Stämpfli Journal: PLoS One Date: 2010-10-12 Impact factor: 3.240
Authors: Prescott G Woodruff; Almut Ellwanger; Margaret Solon; Christopher J Cambier; Kent E Pinkerton; Laura L Koth Journal: COPD Date: 2009-04 Impact factor: 2.409