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Literature DB >> 12475393

Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.

Philippe Soubeyran¹, Ana Barac, Iwona Szymkiewicz, Ivan Dikic.

Abstract

The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.

Entities: Gene Species

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Year: 2003 PMID： 12475393 PMCID： PMC1223168 DOI： 10.1042/BJ20021539

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

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