Literature DB >> 12475363

Altered diurnal pattern of salivary substance P in adults with developmental disabilities and chronic self-injury.

Frank J Symons1, Kelly A Sutton, Cheryl Walker, James W Bodfish.   

Abstract

Morning and afternoon salivary substance P and cortisol levels were measured in 26 adults with chronic self-injurious behavior (SIB) and severe developmental disabilities and compared with matched controls without SIB. Chronic SIB was associated with an altered diurnal pattern of salivary substance P relative to matched controls, characterized primarily by lower levels of morning substance P, which were significantly correlated with overall severity of SIB. There was a trend for SIB subjects to exhibit higher levels of cortisol, which was significantly correlated with overall severity of SIB. These results support a model of altered nociception and possible stress-induced analgesia among individuals with developmental disability and chronic SIB.

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Year:  2003        PMID： 12475363     DOI： 10.1352/0895-8017(2003)108<0013:ADPOSS>2.0.CO;2

Source DB:  PubMed          Journal:  Am J Ment Retard        ISSN： 0895-8017


  9 in total

1.  Individual differences in vulnerability for self-injurious behavior: studies using an animal model.

Authors:  Amber M Muehlmann; Jennifer A Wilkinson; Darragh P Devine
Journal:  Behav Brain Res       Date:  2010-10-23       Impact factor: 3.332

2.  Self-injurious behaviour: limbic dysregulation and stress effects in an animal model.

Authors:  A M Muehlmann; S D Kies; C A Turner; S Wolfman; M H Lewis; D P Devine
Journal:  J Intellect Disabil Res       Date:  2011-10-12

Review 3.  Self-injurious behavior in neurodevelopmental disorders: relevance of nociceptive and immune mechanisms.

Authors:  Frank J Symons
Journal:  Neurosci Biobehav Rev       Date:  2011-01-13       Impact factor: 8.989

4.  Peripheral Innervation in Children With Global Developmental Delay: Biomarker for Risk for Self-Injurious Behavior?

Authors:  Frank J Symons; Raymond C Tervo; Chantel C Barney; John Damerow; Mona Selim; Brian McAdams; Shawn Foster; Gwen Wendelschafer Crabb; William Kennedy
Journal:  J Child Neurol       Date:  2015-04-26       Impact factor: 1.987

5.  Evidence of increased non-verbal behavioral signs of pain in adults with neurodevelopmental disorders and chronic self-injury.

Authors:  Frank J Symons; Vicki N Harper; Patrick J McGrath; Lynn M Breau; James W Bodfish
Journal:  Res Dev Disabil       Date:  2008-09-13

6.  A rhesus monkey model of self-injury: effects of relocation stress on behavior and neuroendocrine function.

Authors:  Matthew D Davenport; Corrine K Lutz; Stefan Tiefenbacher; Melinda A Novak; Jerrold S Meyer
Journal:  Biol Psychiatry       Date:  2008-02-27       Impact factor: 13.382

7.  Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model.

Authors:  Yujie Guo; Xun Tang; Jichuan Zhang; Sen Jin; Jinnan Li; Lufeng Ding; Keming Zhang; Chaoyu Yang; Hua Zhou; Xiaobin He; Fuqiang Xu; Guo-Qiang Bi; Lin Xu; Pak-Ming Lau
Journal:  J Neurosci       Date:  2018-05-14       Impact factor: 6.167

8.  Evidence of altered epidermal nerve fiber morphology in adults with self-injurious behavior and neurodevelopmental disorders.

Authors:  Frank J Symons; Gwen Wendelschafer-Crabb; William Kennedy; Ronald Hardrict; Norm Dahl; James W Bodfish
Journal:  Pain       Date:  2007-09-11       Impact factor: 6.961

9.  Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders.

Authors:  Frank J Symons; Jason J Wolff; Laura S Stone; Tony K Y Lim; James W Bodfish
Journal:  J Neurodev Disord       Date:  2011-04-12       Impact factor: 4.025
  9 in total

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