Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The use of polymer heteronuclei for crystalline polymorph selection.

Literature DB >> 12475310

The use of polymer heteronuclei for crystalline polymorph selection.

Meidong Lang¹, Adam L Grzesiak, Adam J Matzger.

Abstract

A method for the production of crystalline polymorphs from solution is described which utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This method provides a new paradigm for polymorph selection, where solvent and temperature conditions can be chosen on the basis of process considerations and the polymer heteronucleus can be varied for specific polymorph production.

Entities: Chemical

Year: 2002 PMID： 12475310 DOI： 10.1021/ja0286526

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

Keyword Cloud
Cited

24 in total

1. Polymorphs and hydrates of acyclovir.

Authors: Katie M Lutker; Rosalynn Quiñones; Jiadi Xu; Ayyalusamy Ramamoorthy; Adam J Matzger
Journal: J Pharm Sci Date: 2010-11-04 Impact factor: 3.534

2. Materials engineering of solid-state dosage forms.

Authors: Tonglei Li
Journal: Pharm Res Date: 2007-11-06 Impact factor: 4.200

3. Effects of moisture and residual solvent on the phase stability of orthorhombic paracetamol.

Authors: Kyriakos Kachrimanis; Katharina Fucke; Michael Noisternig; Bernd Siebenhaar; Ulrich J Griesser
Journal: Pharm Res Date: 2008-06 Impact factor: 4.200

4. Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement.

Authors: Sabiruddin Mirza; Inna Miroshnyk; Jyrki Heinämäki; Osmo Antikainen; Jukka Rantanen; Pia Vuorela; Heikki Vuorela; Jouko Yliruusi
Journal: AAPS PharmSciTech Date: 2009-01-30 Impact factor: 3.246

5. Heterogeneous nucleation of polymorphs on polymer surfaces: polymer-molecule interactions using a Coulomb and van der Waals model.

Authors: Nanna Wahlberg; Anders Ø Madsen; Kurt V Mikkelsen
Journal: J Mol Model Date: 2018-06-09 Impact factor: 1.810

The use of polymer heteronuclei for crystalline polymorph selection.

1. Polymorphs and hydrates of acyclovir.

2. Materials engineering of solid-state dosage forms.

3. Effects of moisture and residual solvent on the phase stability of orthorhombic paracetamol.

4. Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement.

5. Heterogeneous nucleation of polymorphs on polymer surfaces: polymer-molecule interactions using a Coulomb and van der Waals model.

6. Probing the Interplay between Amorphous Solid Dispersion Stability and Polymer Functionality.

7. Polymorph Discrimination using Low Wavenumber Raman Spectroscopy.

8. Polymorph farming of acetaminophen and sulfathiazole on a chip.

9. Unmasking a third polymorph of a benchmark crystal-structure-prediction compound.

10. Crystal polymorphism in a carbamazepine derivative: oxcarbazepine.