Literature DB >> 12474126

[Reconstruction of the superstructure of the stapes in guinea pigs with biovitro ceramic and silicone foil].

P Dost1, S Ellermann, N N Missfeldt, K Jahnke.   

Abstract

BACKGROUND: The reconstruction of the stapes superstructure is still a problem. Efforts for the fixation of implants on the footplate did not show satisfying results yet.
METHODS: In 6 guinea pigs a biovitro ceramic (Bioverit) was placed on the stapes footplate after removal of the superstructure. The exclusive bony fixation of the implants on the footplate should be achieved by the use of silicone foils. For control purposes replantation of autologous ossicles was done in one group of 3 animals and a sham operation was performed without any use of implants in the other group of 6 guinea pigs.
RESULTS: After 21 weeks not only bony fixation of the implant with the footplate was observed, but furthermore with the wall of the middle ear. Bone formation was detected along the silicone foils. In the first control group of animals we found bony fixation of the replanted ossicles and even a bow-shaped reconstruction of the stapes superstructure in the second.
CONCLUSIONS: The guinea pig was not an ideal model for questions of middle ear reconstructions due to its enormous potential for bone formation. In this animal model bony fixation of glass-ceramic with the stapes-footplate could be induced.

Entities:  

Mesh:

Substances:

Year:  2002        PMID: 12474126     DOI: 10.1007/s00106-002-0641-9

Source DB:  PubMed          Journal:  HNO        ISSN: 0017-6192            Impact factor:   1.284


  4 in total

1.  [Biomaterial studies in cultures of human stapedial bone-like cells].

Authors:  P Dost; M Wiemann; W J F ten Cate
Journal:  HNO       Date:  2005-06       Impact factor: 1.284

2.  [Computer-assisted orbital floor reconstruction. Use of a CAD/CAM implant with intraoperative contact-free 3D endo- and exophthalmometry].

Authors:  T V Kühnel; E Vairaktaris; C Alexiou; K A Schlegel; F W Neukam; E Nkenke
Journal:  HNO       Date:  2008-11       Impact factor: 1.284

3.  Biomaterials in skull base surgery.

Authors:  Wolfgang Maier
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2011-03-10

Review 4.  Tympanoplasty - news and new perspectives.

Authors:  Marcus Neudert; Thomas Zahnert
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2017-12-18
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.