PURPOSE: The aim of the current study was to find out the significance of the immunohistochemical expression of pRb2/p130, which is a member of the retinoblastoma gene family, in squamous cell carcinoma of the esophagus. METHODS: We analyzed immunohistochemically the expression of pRb2/p130 of 107 squamous cell carcinomas (SCCs) of the esophagus and the correlation of pRb2/p130 expression with clinicopathological features was investigated. RESULTS: Expression of pRb2/p130 was observed in 42 SCCs (39.3%). There was a significant correlation of pRb2/p130 expression with the histological type of well-differentiated SCC (P< 0.0001). The survival rate of patients with esophageal SCCs expressing pRb2/p130 was significantly better than that of patients with tumors without pRb2/p130 expression (P= 0.016). A multivariate analysis demonstrated that pRb2/p130 expression (P= 0.026), venous invasion (P= 0.028), and TNM stage (P= 0.044) were independent prognostic indicators in patients with esophageal SCCs. CONCLUSIONS: Differentiation of esophageal SCC might be partially mediated by the pRb2/p130 gene, and pRb2/p130 expression can additionally be an indicator of the better prognosis of patients with esophageal SCCs.
PURPOSE: The aim of the current study was to find out the significance of the immunohistochemical expression of pRb2/p130, which is a member of the retinoblastoma gene family, in squamous cell carcinoma of the esophagus. METHODS: We analyzed immunohistochemically the expression of pRb2/p130 of 107 squamous cell carcinomas (SCCs) of the esophagus and the correlation of pRb2/p130 expression with clinicopathological features was investigated. RESULTS: Expression of pRb2/p130 was observed in 42 SCCs (39.3%). There was a significant correlation of pRb2/p130 expression with the histological type of well-differentiated SCC (P< 0.0001). The survival rate of patients with esophageal SCCs expressing pRb2/p130 was significantly better than that of patients with tumors without pRb2/p130 expression (P= 0.016). A multivariate analysis demonstrated that pRb2/p130 expression (P= 0.026), venous invasion (P= 0.028), and TNM stage (P= 0.044) were independent prognostic indicators in patients with esophageal SCCs. CONCLUSIONS: Differentiation of esophageal SCC might be partially mediated by the pRb2/p130 gene, and pRb2/p130 expression can additionally be an indicator of the better prognosis of patients with esophageal SCCs.
Authors: S M Pupa; C M Howard; A M Invernizzi; R De Vecchi; C Giani; P P Claudio; M I Colnaghi; A Giordano; S Ménard Journal: Oncogene Date: 1999-01-21 Impact factor: 9.867
Authors: C M Howard; P P Claudio; G L Gallia; J Gordon; G G Giordano; W W Hauck; K Khalili; A Giordano Journal: J Natl Cancer Inst Date: 1998-10-07 Impact factor: 13.506
Authors: M Furihata; T Ishikawa; A Inoue; C Yoshikawa; H Sonobe; Y Ohtsuki; K Araki; S Ogoshi Journal: Clin Cancer Res Date: 1996-10 Impact factor: 12.531
Authors: R S Yeung; D W Bell; J R Testa; X Mayol; A Baldi; X Graña; K Klinga-Levan; A G Knudson; A Giordano Journal: Oncogene Date: 1993-12 Impact factor: 9.867