| Literature DB >> 12473345 |
Alicia Algeciras-Schimnich1, Bryan C Barnhart, Marcus E Peter.
Abstract
Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.Mesh:
Substances:
Year: 2002 PMID: 12473345 DOI: 10.1016/s0955-0674(02)00384-8
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN: 0955-0674 Impact factor: 8.382