| Literature DB >> 12470832 |
Alexander Bürkle1, Sascha Beneke, Christine Brabeck, Alan Leake, Ralph Meyer, Marie-Laure Muiras, Ragen Pfeiffer.
Abstract
Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12470832 DOI： 10.1016/s0531-5565(02)00144-4
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032