Literature DB >> 12470729

Modular design of artificial transcription factors.

Aseem Z Ansari1, Anna K Mapp.   

Abstract

Eukaryotic transcription factors are composed of interchangeable modules. This has led to the design of a wide variety of modular artificial transcription factors (ATFs) that can stimulate or inhibit the expression of targeted genes. The ability to regulate the expression of any targeted gene using a 'programmable' ATF offers a powerful tool for functional genomics and bears tremendous promise in developing the field of transcription-based therapeutics.

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Year:  2002        PMID： 12470729     DOI： 10.1016/s1367-5931(02)00377-0

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  27 in total

1.  Directed evolution of specific receptor-ligand pairs for use in the creation of gene switches.

Authors:  Karuppiah Chockalingam; Zhilei Chen; John A Katzenellenbogen; Huimin Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-05       Impact factor: 11.205

2.  Defining the sequence-recognition profile of DNA-binding molecules.

Authors:  Christopher L Warren; Natasha C S Kratochvil; Karl E Hauschild; Shane Foister; Mary L Brezinski; Peter B Dervan; George N Phillips; Aseem Z Ansari
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-17       Impact factor: 11.205

3.  Minimization of a protein-DNA dimerizer.

Authors:  Ryan L Stafford; Hans-Dieter Arndt; Mary L Brezinski; Aseem Z Ansari; Peter B Dervan
Journal:  J Am Chem Soc       Date:  2007-02-10       Impact factor: 15.419

4.  Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides.

Authors:  Bo Liu; Thomas Kodadek
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

Review 5.  Nuclear magnetic resonance analysis of protein-DNA interactions.

Authors:  S Campagne; V Gervais; A Milon
Journal:  J R Soc Interface       Date:  2011-03-09       Impact factor: 4.118

Review 6.  Transcriptional switches: chemical approaches to gene regulation.

Authors:  Lori W Lee; Anna K Mapp
Journal:  J Biol Chem       Date:  2010-02-10       Impact factor: 5.157

Review 7.  Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.

Authors:  Asuka Eguchi; Garrett O Lee; Fang Wan; Graham S Erwin; Aseem Z Ansari
Journal:  Biochem J       Date:  2014-09-15       Impact factor: 3.857

8.  Reprogramming cell fate with a genome-scale library of artificial transcription factors.

Authors:  Asuka Eguchi; Matthew J Wleklinski; Mackenzie C Spurgat; Evan A Heiderscheit; Anna S Kropornicka; Catherine K Vu; Devesh Bhimsaria; Scott A Swanson; Ron Stewart; Parameswaran Ramanathan; Timothy J Kamp; Igor Slukvin; James A Thomson; James R Dutton; Aseem Z Ansari
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-05       Impact factor: 11.205

9.  Reengineering natural design by rational design and in vivo library selection: the HLH subdomain in bHLHZ proteins is a unique requirement for DNA-binding function.

Authors:  Jing Xu; Antonia T De Jong; Gang Chen; Hiu-Kwan Chow; Christopher O Damaso; Adrian Schwartz Mittelman; Jumi A Shin
Journal:  Protein Eng Des Sel       Date:  2010-01-19       Impact factor: 1.650

10.  Tra1 as a screening target for transcriptional activation domain discovery.

Authors:  Chinmay Y Majmudar; Anne E Labut; Anna K Mapp
Journal:  Bioorg Med Chem Lett       Date:  2009-05-18       Impact factor: 2.823
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