Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Natural product guided compound library development.

Literature DB >> 12470251

Natural product guided compound library development.

Rolf Breinbauer¹, Michael Manger, Michael Scheck, Herbert Waldmann.

Abstract

Natural products are biologically validated starting points for the design of combinatorial libraries, as they have a proven record of biological relevance. This special role of natural products in medicinal chemistry and chemical biology can be interpreted in the light of new insights about the domain architecture of proteins gained by structural biology and bioinformatics. In order to fulfil the specific requirements of the individual binding pocket within a domain family it is necessary to optimise the natural product structure by chemical variation. Solid-phase chemistry is becoming an efficient tool for this optimisation process, and recent advances in this field are highlighted in this review article.

Mesh：

Substances：
Biological Factors

Year: 2002 PMID： 12470251 DOI： 10.2174/0929867023368773

Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530

Keyword Cloud
Cited

14 in total

1. Do we need new antibiotics? The search for new targets and new compounds.

Authors: Jaroslav Spížek; Jitka Novotná; Tomáš Rezanka; Arnold L Demain
Journal: J Ind Microbiol Biotechnol Date: 2010-11-18 Impact factor: 3.346

2. Dark chemical matter as a promising starting point for drug lead discovery.

Authors: Anne Mai Wassermann; Eugen Lounkine; Dominic Hoepfner; Gaelle Le Goff; Frederick J King; Christian Studer; John M Peltier; Melissa L Grippo; Vivian Prindle; Jianshi Tao; Ansgar Schuffenhauer; Iain M Wallace; Shanni Chen; Philipp Krastel; Amanda Cobos-Correa; Christian N Parker; John W Davies; Meir Glick
Journal: Nat Chem Biol Date: 2015-10-19 Impact factor: 15.040

10. Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicines.

Authors: Sheng Tian; Youyong Li; Junmei Wang; Xiaojie Xu; Lei Xu; Xiaohong Wang; Lei Chen; Tingjun Hou
Journal: J Cheminform Date: 2013-01-21 Impact factor: 5.514

Natural product guided compound library development.

1. Do we need new antibiotics? The search for new targets and new compounds.

2. Dark chemical matter as a promising starting point for drug lead discovery.

Review 3. What can a chemist learn from nature's macrocycles?--a brief, conceptual view.

Review 4. Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Review 5. Importance of microbial natural products and the need to revitalize their discovery.

Review 6. Neurobiological applications of small molecule screening.

Review 7. Selective MAO-B inhibitors: a lesson from natural products.

Review 8. Natural products: a continuing source of novel drug leads.

9. Emulating the logic of monoterpenoid alkaloid biogenesis to access a skeletally diverse chemical library.

10. Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicines.