OBJECTIVES: To assess whether bacterial vaginosis or chlamydial infection before 10 weeks' gestation is associated with miscarriage before 16 weeks. DESIGN: Prospective cohort study. SETTING: 32 general practices and five family planning clinics in south London. PARTICIPANTS: 1216 pregnant women, mean age 31, presenting before 10 weeks' gestation. MAIN OUTCOME MEASURE: Prevalence of miscarriage before 16 weeks' gestation. RESULTS: 121 of 1214 women (10.0%, 95% confidence interval 8.3% to 11.7%) miscarried before 16 weeks. 174 of 1201 women (14.5%, 12.5% to 16.5%) had bacterial vaginosis. Compared with women who were negative for bacterial vaginosis those who were positive had a relative risk of miscarriage before 16 weeks' gestation of 1.2 (0.7 to 1.9). Bacterial vaginosis was, however, associated with miscarriage in the second trimester at 13-15 weeks (3.5, 1.2 to 10.3). Only 29 women (2.4%, 1.5% to 3.3%) had chlamydial infection, of whom one miscarried (0.32, 0.04 to 2.30). CONCLUSION: Bacterial vaginosis is not strongly predictive of early miscarriage but may be a predictor after 13 weeks' gestation. The prevalence of Chlamydia was too low to assess the risk, but it is unlikely to be a major risk factor in pregnant women.
OBJECTIVES: To assess whether bacterial vaginosis or chlamydial infection before 10 weeks' gestation is associated with miscarriage before 16 weeks. DESIGN: Prospective cohort study. SETTING: 32 general practices and five family planning clinics in south London. PARTICIPANTS: 1216 pregnant women, mean age 31, presenting before 10 weeks' gestation. MAIN OUTCOME MEASURE: Prevalence of miscarriage before 16 weeks' gestation. RESULTS: 121 of 1214 women (10.0%, 95% confidence interval 8.3% to 11.7%) miscarried before 16 weeks. 174 of 1201 women (14.5%, 12.5% to 16.5%) had bacterial vaginosis. Compared with women who were negative for bacterial vaginosis those who were positive had a relative risk of miscarriage before 16 weeks' gestation of 1.2 (0.7 to 1.9). Bacterial vaginosis was, however, associated with miscarriage in the second trimester at 13-15 weeks (3.5, 1.2 to 10.3). Only 29 women (2.4%, 1.5% to 3.3%) had chlamydial infection, of whom one miscarried (0.32, 0.04 to 2.30). CONCLUSION:Bacterial vaginosis is not strongly predictive of early miscarriage but may be a predictor after 13 weeks' gestation. The prevalence of Chlamydia was too low to assess the risk, but it is unlikely to be a major risk factor in pregnant women.
Authors: J C Carey; M A Klebanoff; J C Hauth; S L Hillier; E A Thom; J M Ernest; R P Heine; R P Nugent; M L Fischer; K J Leveno; R Wapner; M Varner Journal: N Engl J Med Date: 2000-02-24 Impact factor: 91.245
Authors: J A McGregor; J I French; R Parker; D Draper; E Patterson; W Jones; K Thorsgard; J McFee Journal: Am J Obstet Gynecol Date: 1995-07 Impact factor: 8.661
Authors: Deborah B Nelson; Scarlett Bellamy; Irving Nachamkin; Roberta B Ness; George A Macones; Lynne Allen-Taylor Journal: Fertil Steril Date: 2007-04-16 Impact factor: 7.329
Authors: Vanessa L Short; Jørgen S Jensen; Deborah B Nelson; Pamela J Murray; Roberta B Ness; Catherine L Haggerty Journal: Infect Dis Obstet Gynecol Date: 2010-03-31