Keisuke Ishii1, Yoichi Aoki, Masaru Sasaki, Kenichi Tanaka. 1. Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi dori, Niigata 951-8510, Japan.
Abstract
BACKGROUND: Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin therapy is a previously unreported complication. CASE: A 63-year-old woman with stage Ib2 squamous cell carcinoma of the cervix was treated with intraarterial cisplatin infusion in a neoadjuvant setting. Four days following the second course of chemotherapy, she became drowsy with severe fatigue and decreased mental awareness. Blood tests showed sodium of 110 mEq/L. Urine and plasma osmolarities were 308 and 240 mOsm/kg, respectively, confirming the diagnosis of a syndrome of inappropriate secretion of antidiuretic hormone induced by intra-arterial cisplatin infusion. CONCLUSION: The potential for development of clinically significant hyponatremia early in the course of cisplatin therapy with any infusion routes emphasizes the need to closely monitor patients.
BACKGROUND: Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin therapy is a previously unreported complication. CASE: A 63-year-old woman with stage Ib2squamous cell carcinoma of the cervix was treated with intraarterial cisplatin infusion in a neoadjuvant setting. Four days following the second course of chemotherapy, she became drowsy with severe fatigue and decreased mental awareness. Blood tests showed sodium of 110 mEq/L. Urine and plasma osmolarities were 308 and 240 mOsm/kg, respectively, confirming the diagnosis of a syndrome of inappropriate secretion of antidiuretic hormone induced by intra-arterial cisplatin infusion. CONCLUSION: The potential for development of clinically significant hyponatremia early in the course of cisplatin therapy with any infusion routes emphasizes the need to closely monitor patients.
Authors: Deniz Yucel; Erinie Mekheal; Brooke Kania; Polina Aron; Ashima Kapoor; Radhika P Tailor; Michael Maroules Journal: J Community Hosp Intern Med Perspect Date: 2022-09-09