| Literature DB >> 12467626 |
Hsing-Pang Hsieh1, Jing-Ping Liou, Ying-Ting Lin, Neeraj Mahindroo, Jang-Yang Chang, Yung-Ning Yang, Shuenn-Shing Chern, Uan-Kang Tan, Chun-Wei Chang, Tung-Wei Chen, Chi-Hung Lin, Ying-Ying Chang, Chiung-Chiu Wang.
Abstract
Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.Entities:
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Year: 2003 PMID： 12467626 DOI： 10.1016/s0960-894x(02)00850-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823