Literature DB >> 12467622

Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells.

Hiroki Kakuta1, Yukiko Koiso, Kazuo Nagasawa, Yuichi Hashimoto.   

Abstract

Non-peptide, small-molecular, non-competitive inhibitors of puromycin-sensitive aminopeptidase (PSA), that is, 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione (PAQ-22, 3) and its 1N-methyl analogue (MPAQ-22 4), were structurally modified to afford fluorescent bioprobes, ANTAQ (5) and DAMPAQ-22 (6). The cellular localization of PSA could be visualized by the use of these fluorescent bioprobes.

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Year:  2003        PMID： 12467622     DOI： 10.1016/s0960-894x(02)00845-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.

Authors:  Fiona M Menzies; Raphael Hourez; Sara Imarisio; Marcel Raspe; Oana Sadiq; Dhia Chandraratna; Cahir O'Kane; Kenneth L Rock; Eric Reits; Alfred L Goldberg; David C Rubinsztein
Journal:  Hum Mol Genet       Date:  2010-09-09       Impact factor: 6.150

2.  Design, Synthesis, Anti-Varicella-Zoster and Antimicrobial Activity of (Isoxazolidin-3-yl)Phosphonate Conjugates of N1-Functionalised Quinazoline-2,4-Diones.

Authors:  Magdalena Łysakowska; Iwona E Głowacka; Graciela Andrei; Dominique Schols; Robert Snoeck; Paweł Lisiecki; Magdalena Szemraj; Dorota G Piotrowska
Journal:  Molecules       Date:  2022-10-02       Impact factor: 4.927

3.  A puromycin-sensitive aminopeptidase is essential for meiosis in Arabidopsis thaliana.

Authors:  Eugenio Sánchez-Morán; Gareth H Jones; F Christopher H Franklin; Juan Luis Santos
Journal:  Plant Cell       Date:  2004-11       Impact factor: 11.277

4.  Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.

Authors:  Mingqun Lin; Hongyan Liu; Qingming Xiong; Hua Niu; Zhihui Cheng; Akitsugu Yamamoto; Yasuko Rikihisa
Journal:  Autophagy       Date:  2016-08-19       Impact factor: 16.016
  4 in total

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